Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)
1_MAGPG 6_ WGPPR 11_ LDGFI 16_ LTERL 21_ GSGTY 26_ ATVYK 31_ AYAKK 36_ DTREV 41_ VAIKC 46_ VAKKS 51_ LNKAS 56_ VENLL 61_ TEIEI 66_ LKGIR 71_ HPHIV 76_ QLKDF 81_ QWDSD 86_ NIYLI 91_ MEFCA 96_ GGDLS 101_ RFIHT 106_ RRILP 111_ EKVAR 116_ VFMQQ 121_ LASAL 126_ QFLHE 131_ RNISH 136_ LDLKP 141_ QNILL 146_ SSLEK 151_ PHLKL 156_ ADFGF 161_ AQHMS 166_ PWDEK 171_ HVLRG 176_ SPLYM 181_ APEMV 186_ CQRQY 191_ DARVD 196_ LWSMG 201_ VILYE 206_ ALFGQ 211_ PPFAS 216_ RSFSE 221_ LEEKI 226_ RSNRV 231_ IELPL 236_ RPLLS 241_ RDCRD 246_ LLQRL 251_ LERDP 256_ SRRIS 261_ FQDFF 266_ AHPWV 271_ DLEHM 276_ PSGES 281_ LGRAT 286_ ALVVQ 291_ AVKKD 296_ QEGDS 301_ AAALS 306_ LYCKA 311_ LDFFV 316_ PALHY 321_ EVDAQ 326_ RKEAI 331_ KAKVG 336_ QYVSR 341_ AEELK 346_ AIVSS 351_ SNQAL 356_ LRQGT 361_ SARDL 366_ LREMA 371_ RDKPR 376_ LLAAL 381_ EVASA 386_ AMAKE 391_ EAAGG 396_ EQDAL 401_ DLYQH 406_ SLGEL 411_ LLLLA 416_ AEPPG 421_ RRREL 426_ LHTEV 431_ QNLMA 436_ RAEYL 441_ KEQVK 446_ MRESR 451_ WEADT 456_ LDKEG 461_ LSESV 466_RSSCT
1: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy