Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
1_MYFLT 6_ PILVA 11_ ILCIL 16_ VVWIF 21_ KNADR 26_ SMEKK 31_ KGEPR 36_ TRAEA 41_ RPWVD 46_ EDLKD 51_ SSDLH 56_ QAEED 61_ ADEWQ 66_ ESEEN 71_ VEHIP 76_ FSHNH 81_ YPEKE 86_ MVKRS 91_ QEFYE 96_ LLNKR 101_ RSVRF 106_ ISNEQ 111_ VPMEV 116_ IDNVI 121_ RTAGT 126_ APSGA 131_ HTEPW 136_ TFVVV 141_ KDPDV 146_ KHKIR 151_ KIIEE 156_ EEEIN 161_ YMKRM 166_ GHRWV 171_ TDLKK 176_ LRTNW 181_ IKEYL 186_ DTAPI 191_ LILIF 196_ KQVHG 201_ FAANG 206_ KKKVH 211_ YYNEI 216_ SVSIA 221_ CGILL 226_ AALQN 231_ AGLVT 236_ VTTTP 241_ LNCGP 246_ RLRVL 251_ LGRPA 256_ HEKLL 261_ MLLPV 266_ GYPSK 271_ EATVP 276_ DLKRK 281_PLDQI
1: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438)