Transmembrane protein 65
1_MSRLL 6_ PLLRS 11_ RTARS 16_ LRPGP 21_ AAAAA 26_ PRPPS 31_ WCCCG 36_ RGLLA 41_ LAPPG 46_ GLPGG 51_ PRRLG 56_ THPKK 61_ EPMEA 66_ LNTAQ 71_ GARDF 76_ IYSLH 81_ STERS 86_ CLLKE 91_ LHRFE 96_ SIAIA 101_ QEKLE 106_ APPPT 111_ PGQLR 116_ YVFIH 121_ NAIPF 126_ IGFGF 131_ LDNAI 136_ MIVAG 141_ THIEM 146_ SIGII 151_ LGIST 156_ MAAAA 161_ LGNLV 166_ SDLAG 171_ LGLAG 176_ YVEAL 181_ ASRLG 186_ LSIPD 191_ LTPKQ 196_ VDMWQ 201_ TRLST 206_ HLGKA 211_ VGVTI 216_ GCILG 221_ MFPLI 226_ FFGGG 231_EEDEK
1: Essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart. Its association with SCN1B is required for stabilizing the perinexus in the ICD and for localization of GJA1 and SCN5A to the ICD. May regulate the function of the gap junction protein GJA1 and may contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037)