F-box only protein 38
1_MGPRK 6_ KSVKT 11_ CIMNN 16_ EIPEE 21_ MTADE 26_ TKDYM 31_ NQLSH 36_ EVLCH 41_ IFRYL 46_ PLQDI 51_ MCMEC 56_ LSRKL 61_ KEAVT 66_ LYLRV 71_ VRVVD 76_ LCAGR 81_ WWEYM 86_ PSGFT 91_ DASFL 96_ TLLKK 101_ MPDVE 106_ QLYGL 111_ HPRYL 116_ ERRRV 121_ RGHEA 126_ FSIPG 131_ VLEAL 136_ QACPN 141_ LVGVE 146_ TSHLE 151_ LVESI 156_ WTYMP 161_ HVHIL 166_ GKFRN 171_ RNGAF 176_ PIPPE 181_ NKLKI 186_ PIGAK 191_ IQTLH 196_ LVGVN 201_ VPEIP 206_ CIPML 211_ RHLYM 216_ KWVRL 221_ TKPQP 226_ FKDFL 231_ CISLR 236_ TFVMR 241_ NCAGP 246_ TNSLK 251_ YVPLV 256_ TGLAS 261_ ARNLE 266_ HLEMV 271_ RVPFL 276_ GGLIQ 281_ HVVED 286_ SWRSG 291_ GFRNL 296_ HTIVL 301_ GACKN 306_ ALEVD 311_ LGYLI 316_ ITAAR 321_ RLHEV 326_ RIQPS 331_ LTKDG 336_ VFSAL 341_ KMAEL 346_ EFPQF 351_ ETLHL 356_ GYVDE 361_ FLLQS 366_ RMANA 371_ DLVKY 376_ GLADV 381_ VENPG 386_ IITDI 391_ GMKAV 396_ NEVFS 401_ CIKYL 406_ AIYNC 411_ PHLHN 416_ PYNWI 421_ SDHSR 426_ WTRLV 431_ DINLV 436_ RCHAL 441_ KLDSF 446_ GQFIE 451_ LLPSL 456_ EFISL 461_ DQMFR 466_ EPPKG 471_ CARVG 476_ LSAGT 481_ GIGVS 486_ SALVS 491_ NQNSN 496_ NDDNN 501_ AQNNN 506_ ANIHD 511_ NNHHH 516_ PDDSD 521_ EENDF 526_ RQDLQ 531_ PGEQQ 536_ FAADA 541_ LNEME 546_ DIVQE 551_ DGEVV 556_ AESGN 561_ NTPAH 566_ SQAII 571_ PVDVD 576_ EEQAG 581_ PSGLQ 586_ RVVKP 591_ TSITV 596_ HDSES 601_ DDEED 606_ SLELQ 611_ EVWIP 616_ KNGTR 621_ RYSER 626_ EEKTG 631_ ESVQS 636_ RELSV 641_ SGKGK 646_ TPLRK 651_ RYNSH 656_ QMGQS 661_ KQFPL 666_ EESSC 671_ EKGCQ 676_ VTSEQ 681_ IKADM 686_ KAARD 691_ IPEKK 696_ KNKDV 701_ YPSCS 706_ STTAS 711_ TVGNS 716_ SSHNT 721_ ASQSP 726_ DFVRT 731_ VNSGG 736_ SSEPS 741_ PTEVD 746_ VSRQC 751_ ACSPG 756_ GSEDS 761_ EAMEE 766_ GDAES 771_ SVCPR 776_ CCCHR 781_ PQESQ 786_ RRTSR 791_ CSDEE 796_ RPSTS 801_ RACVV 806_ NGPDG 811_ TRSAF 816_ SFRTL 821_ PQGGS 826_ SGPAH 831_ DERTN 836_ GSGSG 841_ ATGED 846_ RRGSS 851_ QPESC 856_ DVQSN 861_ EDYPR 866_ RPLTR 871_ ARSRL 876_ SHVLL 881_ VSESE 886_ VAKTK 891_ PRHAM 896_ KRKRT 901_ ADKST 906_ STSDP 911_ VIEDD 916_ HVQVL 921_ VLKSK 926_ NLVGV 931_ TMTNC 936_ GITDL 941_ VLKDC 946_ PKMMF 951_ IHATR 956_ CRVLK 961_ HLKVE 966_ NAPIV 971_ NRFDY 976_ AQCKK 981_ LNMDQ 986_ VLDQI 991_ LRMPP 996_ ERNRI 1001_ IYLRP 1006_ MQQVD 1011_ TLTLE 1016_ QKLFS 1021_ GPYPY 1026_ HICII 1031_ HEFSN 1036_ PPNVR 1041_ NKVRI 1046_ RSWMD 1051_ TIANI 1056_ NQELI 1061_ KYEFF 1066_ PEATR 1071_ SEEDL 1076_ KKYPK 1081_ YPWGR 1086_ EIYTL 1091_ EGVVD 1096_ GAPYS 1101_ MISDF 1106_ PWLRS 1111_ LRAAE 1116_ PNSFA 1121_ RYDFE 1126_ DDEES 1131_ TIYAP 1136_ RRKGQ 1141_ LSADI 1146_ CMETI 1151_ GEEIS 1156_ EMRQM 1161_ KKGVF 1166_ QRVVA 1171_ IFIHY 1176_ CDVNG 1181_EPVED
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity)