Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)
1_MNVRR 6_ VESIS 11_ AQLEE 16_ ASSTG 21_ GFLYA 26_ QNSTK 31_ RSIKE 36_ RLMKL 41_ LPCSA 46_ AKTSS 51_ PAIQN 56_ SVEDE 61_ LEMAT 66_ VRHRP 71_ EALEL 76_ LEAQS 81_ KFTKK 86_ ELQIL 91_ YRGFK 96_ NECPS 101_ GVVNE 106_ ETFKE 111_ IYSQF 116_ FPQGD 121_ STTYA 126_ HFLFN 131_ AFDTD 136_ HNGAV 141_ SFEDF 146_ IKGLS 151_ ILLRG 156_ TVQEK 161_ LNWAF 166_ NLYDI 171_ NKDGY 176_ ITKEE 181_ MLDIM 186_ KAIYD 191_ MMGKC 196_ TYPVL 201_ KEDAP 206_ RQHVE 211_ TFFQK 216_ MDKNK 221_ DGVVT 226_ IDEFI 231_ ESCQK 236_ DENIM 241_RSMQL
1: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane