Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)
1_MRSSC 6_ VLLTA 11_ LVALA 16_ AYYVY 21_ IPLPG 26_ SVSDP 31_ WKLML 36_ LDATF 41_ RGAQQ 46_ VSNLI 51_ HYLGL 56_ SHHLL 61_ ALNFI 66_ IVSFG 71_ KKSAW 76_ SSAQV 81_ KVTDT 86_ DFDGV 91_ EVRVF 96_ EGPPK 101_ PEEPL 106_ KRSVV 111_ YIHGG 116_ GWALA 121_ SAKIR 126_ YYDEL 131_ CTAMA 136_ EELNA 141_ VIVSI 146_ EYRLV 151_ PKVYF 156_ PEQIH 161_ DVVRA 166_ TKYFL 171_ KPEVL 176_ QKYMV 181_ DPGRI 186_ CISGD 191_ SAGGN 196_ LAAAL 201_ GQQFT 206_ QDASL 211_ KNKLK 216_ LQALI 221_ YPVLQ 226_ ALDFN 231_ TPSYQ 236_ QNVNT 241_ PILPR 246_ YVMVK 251_ YWVDY 256_ FKGNY 261_ DFVQA 266_ MIVNN 271_ HTSLD 276_ VEEAA 281_ AVRAR 286_ LNWTS 291_ LLPAS 296_ FTKNY 301_ KPVVQ 306_ TTGNA 311_ RIVQE 316_ LPQLL 321_ DARSA 326_ PLIAD 331_ QAVLQ 336_ LLPKT 341_ YILTC 346_ EHDVL 351_ RDDGI 356_ MYAKR 361_ LESAG 366_ VEVTL 371_ DHFED 376_ GFHGC 381_ MIFTS 386_ WPTNF 391_ SVGIR 396_ TRNSY 401_IKWLD
1: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608)