Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)
1_MASAD 6_ KNGGS 11_ VSSVS 16_ SSRLQ 21_ SRKPP 26_ NLSIT 31_ IPPPE 36_ KETQA 41_ PGEQD 46_ SMLPE 51_ GFQNR 56_ RLKKS 61_ QPRTW 66_ AAHTT 71_ ACPPS 76_ FLPKR 81_ KNPAY 86_ LKSVS 91_ LQEPR 96_ SRWQE 101_ SSEKR 106_ PGFRR 111_ QASLS 116_ QSIRK 121_ GAAQW 126_ FGVSG 131_ DWEGQ 136_ RQQWQ 141_ RRSLH 146_ HCSMR 151_ YGRLK 156_ ASCQR 161_ DLELP 166_ SQEAP 171_ SFQGT 176_ ESPKP 181_ CKMPK 186_ IVDPL 191_ ARGRA 196_ FRHPE 201_ EMDRP 206_ HAPHP 211_ PLTPG 216_ VLSLT 221_ SFTSV 226_ RSGYS 231_ HLPRR 236_ KRMSV 241_ AHMSL 246_ QAAAA 251_ LLKGR 256_ SVLDA 261_ TGQRC 266_ RVVKR 271_ SFAFP 276_ SFLEE 281_ DVVDG 286_ ADTFD 291_ SSFFS 296_ KEEMS 301_ SMPDD 306_ VFESP 311_ PLSAS 316_ YFRGI 321_ PHSAS 326_ PVSPD 331_ GVQIP 336_ LKEYG 341_ RAPVP 346_ GPRRG 351_ KRIAS 356_ KVKHF 361_ AFDRK 366_ KRHYG 371_ LGVVG 376_ NWLNR 381_ SYRRS 386_ ISSTV 391_ QRQLE 396_ SFDSH 401_ RPYFT 406_ YWLTF 411_ VHVII 416_ TLLVI 421_ CTYGI 426_ APVGF 431_ AQHVT 436_ TQLVL 441_ RNKGV 446_ YESVK 451_ YIQQE 456_ NFWVG 461_ PSSID 466_ LIHLG 471_ AKFSP 476_ CIRKD 481_ GQIEQ 486_ LVLRE 491_ RDLER 496_ DSGCC 501_ VQNDH 506_ SGCIQ 511_ TQRKD 516_ CSETL 521_ ATFVK 526_ WQDDT 531_ GPPMD 536_ KSDLG 541_ QKRTS 546_ GAVCH 551_ QDPRT 556_ CEEPA 561_ SSGAH 566_ IWPDD 571_ ITKWP 576_ ICTEQ 581_ ARSNH 586_ TGFLH 591_ MDCEI 596_ KGRPC 601_ CIGTK 606_ GSCEI 611_ TTREY 616_ CEFMH 621_ GYFHE 626_ EATLC 631_ SQVHC 636_ LDKVC 641_ GLLPF 646_ LNPEV 651_ PDQFY 656_ RLWLS 661_ LFLHA 666_ GVVHC 671_ LVSVV 676_ FQMTI 681_ LRDLE 686_ KLAGW 691_ HRIAI 696_ IFILS 701_ GITGN 706_ LASAI 711_ FLPYR 716_ AEVGP 721_ AGSQF 726_ GLLAC 731_ LFVEL 736_ FQSWP 741_ LLERP 746_ WKAFL 751_ NLSAI 756_ VLFLF 761_ ICGLL 766_ PWIDN 771_ IAHIF 776_ GFLSG 781_ LLLAF 786_ AFLPY 791_ ITFGT 796_ SDKYR 801_ KRALI 806_ LVSLL 811_ AFAGL 816_ FAALV 821_ LWLYI 826_ YPINW 831_ PWIEH 836_ LTCFP 841_ FTSRF 846_ CEKYE 851_LDQVL
1: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own