BRCA1-associated ATM activator 1 (BRCA1-associated protein required for ATM activation protein 1)
1_MDPEC 6_ AQLLP 11_ ALCAV 16_ LVDPR 21_ QPVAD 26_ DTCLE 31_ KLLDW 36_ FKTVT 41_ EGESS 46_ VVLLQ 51_ EHPCL 56_ VELLS 61_ HVLKV 66_ QDLSS 71_ GVLSF 76_ SLRLA 81_ GTFAA 86_ QENCF 91_ QYLQQ 96_ GELLP 101_ GLFGE 106_ PGPLG 111_ RATWA 116_ VPTVR 121_ SGWIQ 126_ GLRSL 131_ AQHPS 136_ ALRFL 141_ ADHGA 146_ VDTIF 151_ SLQGD 156_ SSLFV 161_ ASAAS 166_ QLLVH 171_ VLALS 176_ MRGGA 181_ EGQPC 186_ LPGGD 191_ WPACA 196_ QKIMD 201_ HVEES 206_ LCSAA 211_ TPKVT 216_ QALNV 221_ LTTTF 226_ GRCQS 231_ PWTEA 236_ LWVRL 241_ SPRVA 246_ CLLER 251_ DPIPA 256_ AHSFV 261_ DLLLC 266_ VARSP 271_ VFSSS 276_ DGSLW 281_ ETVAR 286_ ALSCL 291_ GPTHM 296_ GPLAL 301_ GILKL 306_ EHCPQ 311_ ALRTQ 316_ AFQVL 321_ LQPLA 326_ CVLKA 331_ TVQAP 336_ GPPGL 341_ LDGTA 346_ DDATT 351_ VDTLL 356_ ASKSS 361_ CAGLL 366_ CRTLA 371_ HLEEL 376_ QPLPQ 381_ RPSPW 386_ PQASL 391_ LGATV 396_ TVLRL 401_ CDGSA 406_ APASS 411_ VGGHL 416_ CGTLA 421_ GCVRV 426_ QRAAL 431_ DFLGT 436_ LSQGT 441_ GPQEL 446_ VTQAL 451_ AVLLE 456_ CLESP 461_ GSSPT 466_ VLKKA 471_ FQATL 476_ RWLLS 481_ SPKTP 486_ GCSDL 491_ GPLIP 496_ QFLRE 501_ LFPVL 506_ QKRLC 511_ HPCWE 516_ VRDSA 521_ LEFLT 526_ QLSRH 531_ WGGQA 536_ DFRCA 541_ LLASE 546_ VPQLA 551_ LQLLQ 556_ DPESY 561_ VRASA 566_ VTAMG 571_ QLSSQ 576_ GLHAP 581_ TSPEH 586_ AEARQ 591_ SLFLE 596_ LLHIL 601_ SVDSE 606_ GFPRR 611_ AVMQV 616_ FTEWL 621_ RDGHA 626_ DAAQD 631_ TEQFV 636_ ATVLQ 641_ AASRD 646_ LDWEV 651_ RAQGL 656_ ELALV 661_ FLGQT 666_ LGPPR 671_ THCPY 676_ AVALP 681_ EVAPA 686_ QPLTE 691_ ALRAL 696_ CHVGL 701_ FDFAF 706_ CALFD 711_ CDRPV 716_ AQKSC 721_ DLLLF 726_ LRDKI 731_ ASYSS 736_ LREAR 741_ GSPNT 746_ ASAEA 751_ TLPRW 756_ RAGEQ 761_ AQPPG 766_ DQEPE 771_ AVLAM 776_ LRSLD 781_ LEGLR 786_ STLAE 791_ SSDHV 796_ EKSPQ 801_ SLLQD 806_ MLATG 811_ GFLQG 816_DEADC
1: Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994)