GATOR complex protein WDR59 (WD repeat-containing protein 59)
1_MAARW 6_ SSENV 11_ VVEFR 16_ DSQAT 21_ AMSVD 26_ CLGQH 31_ AVLSG 36_ RRFLY 41_ IVNLD 46_ APFEG 51_ HRKIS 56_ RQSKW 61_ DIGAV 66_ QWNPH 71_ DSFAH 76_ YFAAS 81_ SNQRV 86_ DLYKW 91_ KDGSG 96_ EVGTT 101_ LQGHT 106_ RVISD 111_ LDWAV 116_ FEPDL 121_ LVTSS 126_ VDTYI 131_ YIWDI 136_ KDTRK 141_ PTVAL 146_ SAVAG 151_ ASQVK 156_ WNKKN 161_ ANCLA 166_ TSHDG 171_ DVRIW 176_ DKRKP 181_ STAVE 186_ YLAAH 191_ LSKIH 196_ GLDWH 201_ PDSEH 206_ ILATS 211_ SQDNS 216_ VKFWD 221_ YRQPR 226_ KYLNI 231_ LPCQV 236_ PVWKA 241_ RYTPF 246_ SNGLV 251_ TVMVP 256_ QLRRE 261_ NSLLL 266_ WNVFD 271_ LNTPV 276_ HTFVG 281_ HDDVV 286_ LEFQW 291_ RKQKE 296_ GSKDY 301_ QLVTW 306_ SRDQT 311_ LRMWR 316_ VDSQM 321_ QRLCA 326_ NDILD 331_ GVDEF 336_ IESIS 341_ LLPEP 346_ EKTLH 351_ TEDTD 356_ HQHTA 361_ SHGEE 366_ EALKE 371_ DPPRN 376_ LLEER 381_ KSDQL 386_ GLPQT 391_ LQQEF 396_ SLINV 401_ QIRNV 406_ NVEMD 411_ AADRS 416_ CTVSV 421_ HCSNH 426_ RVKML 431_ VKFPA 436_ QYPNN 441_ AAPSF 446_ QFINP 451_ TTITS 456_ TMKAK 461_ LLKIL 466_ KDTAL 471_ QKVKR 476_ GQSCL 481_ EPCLR 486_ QLVSC 491_ LESFV 496_ NQEDS 501_ ASSNP 506_ FALPN 511_ SVTPP 516_ LPTFA 521_ RVTTA 526_ YGSYQ 531_ DANIP 536_ FPRTS 541_ GARFC 546_ GAGYL 551_ VYFTR 556_ PMTMH 561_ RAVSP 566_ TEPTP 571_ RSLSA 576_ LSAYH 581_ TGLIA 586_ PMKIR 591_ TEAPG 596_ NLRLY 601_ SGSPT 606_ RSEKE 611_ QVSIS 616_ SFYYK 621_ ERKSR 626_ RWKSK 631_ REGSD 636_ SGNRQ 641_ IKAAG 646_ KVIIQ 651_ DIACL 656_ LPVHK 661_ SLGEL 666_ YILNV 671_ NDIQE 676_ TCQKN 681_ AASAL 686_ LVGRK 691_ DLVQV 696_ WSLAT 701_ VATDL 706_ CLGPK 711_ SDPDL 716_ ETPWA 721_ RHPFG 726_ RQLLE 731_ SLLAH 736_ YCRLR 741_ DVQTL 746_ AMLCS 751_ VFEAQ 756_ SRPQG 761_ LPNPF 766_ GPFPN 771_ RSSNL 776_ VVSHS 781_ RYPSF 786_ TSSGS 791_ CSSMS 796_ DPGLN 801_ TGGWN 806_ IAGRE 811_ AEHLS 816_ SPWGE 821_ SSPEE 826_ LRFGS 831_ LTYSD 836_ PRERE 841_ RDQHD 846_ KNKRL 851_ LDPAN 856_ TQQFD 861_ DFKKC 866_ YGEIL 871_ YRWGL 876_ REKRA 881_ EVLKF 886_ VSCPP 891_ DPHKG 896_ IEFGV 901_ YCSHC 906_ RSEVR 911_ GTQCA 916_ ICKGF 921_ TFQCA 926_ ICHVA 931_ VRGSS 936_ NFCLT 941_ CGHGG 946_ HTSHM 951_ MEWFR 956_ TQEVC 961_ PTGCG 966_CHCLL
1: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210)