DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)
1_MLEDI 6_ SEEDI 11_ WEYKS 16_ KRKPK 21_ RVDPN 26_ NGSKN 31_ ILKSV 36_ EKATD 41_ GKYQS 46_ KRSRN 51_ RKRAA 56_ EAKEV 61_ KDHEV 66_ PLGNA 71_ GCQTS 76_ VASSQ 81_ NSSCG 86_ DGIQQ 91_ TQDKE 96_ TTPGK 101_ LCRTQ 106_ KSQHV 111_ SPKIR 116_ PVYDG 121_ YCPNC 126_ QMPFS 131_ SLIGQ 136_ TPRWH 141_ VFECL 146_ DSPPR 151_ SETEC 156_ PDGLL 161_ CTSTI 166_ PFHYK 171_ RYTHF 176_ LLAQS 181_ RAGDH 186_ PFSSP 191_ SPASG 196_ GSFSE 201_ TKSGV 206_ LCSLE 211_ ERWSS 216_ YQNQT 221_ DNSVS 226_ NDPLL 231_ MTQYF 236_ KKSPS 241_ LTEAS 246_ EKIST 251_ HIQTS 256_ QQALQ 261_ FTDFV 266_ ENDKL 271_ VGVAL 276_ RLANN 281_ SEHIN 286_ LPLPE 291_ NDFSD 296_ CEISY 301_ SPLQS 306_ DEDTH 311_ DIDEK 316_ PDDSQ 321_ EQLFF 326_ TESSK 331_ DGSLE 336_ EDDDS 341_ CGFFK 346_ KRHGP 351_ LLKDQ 356_ DESCP 361_ KVNSF 366_ LTRDK 371_ YDEGL 376_ YRFNS 381_ LNDLS 386_ QPISQ 391_ NNEST 396_ LPYDL 401_ ACTGG 406_ DFVLF 411_ PPALA 416_ GKLAA 421_ SVHQA 426_ TKAKP 431_ DEPEF 436_ HSAQS 441_ NKQKQ 446_ VIEES 451_ SVYNQ 456_ VSLPL 461_ VKSLM 466_ LKPFE 471_ SQVEG 476_ YLSSQ 481_ PTQNT 486_ IRKLS 491_ SENLN 496_ AKNNT 501_ NSACF 506_ CRKAL 511_ EGVPV 516_ GKATI 521_ LNTEN 526_ LSSTP 531_ APKYL 536_ KILPS 541_ GLKYN 546_ ARHPS 551_ TKVMK 556_ QMDIG 561_ VYFGL 566_ PPKRK 571_ EEKLL 576_ GESAL 581_ EGINL 586_ NPVPS 591_ PNQKR 596_ SSQCK 601_ RKAEK 606_ SLSDL 611_ EFDAS 616_ TLHES 621_ QLSVE 626_ LSSER 631_ SQRQK 636_ KRCRK 641_ SNSLQ 646_ EGACQ 651_ KRSDH 656_ LINTE 661_ SEAVN 666_ LSKVK 671_ VFTKS 676_ AHGGL 681_ QRGNK 686_ KIPES 691_ SNVGG 696_ SRKKT 701_ CPFYK 706_ KIPGT 711_ GFTVD 716_ AFQYG 721_ VVEGC 726_ TAYFL 731_ THFHS 736_ DHYAG 741_ LSKHF 746_ TFPVY 751_ CSEIT 756_ GNLLK 761_ NKLHV 766_ QEQYI 771_ HPLPL 776_ DTECI 781_ VNGVK 786_ VVLLD 791_ ANHCP 796_ GAVMI 801_ LFYLP 806_ NGTVI 811_ LHTGD 816_ FRADP 821_ SMERS 826_ LLADQ 831_ KVHML 836_ YLDTT 841_ YCSPE 846_ YTFPS 851_ QQEVI 856_ RFAIN 861_ TAFEA 866_ VTLNP 871_ HALVV 876_ CGTYS 881_ IGKEK 886_ VFLAI 891_ ADVLG 896_ SKVGM 901_ SQEKY 906_ KTLQC 911_ LNIPE 916_ INSLI 921_ TTDMC 926_ SSLVH 931_ LLPMM 936_ QINFK 941_ GLQSH 946_ LKKCG 951_ GKYNQ 956_ ILAFR 961_ PTGWT 966_ HSNKF 971_ TRIAD 976_ VIPQT 981_ KGNIS 986_ IYGIP 991_ YSEHS 996_ SYLEM 1001_ KRFVQ 1006_ WLKPQ 1011_ KIIPT 1016_ VNVGT 1021_ WKSRS 1026_ TMEKY 1031_FREWK
1: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986)