La-related protein 1 (La ribonucleoprotein domain family member 1)
1_MATQV 6_ EPLLP 11_ GGATL 16_ LQAEE 21_ HGGLV 26_ RKKPP 31_ PAPEG 36_ KGEPG 41_ PNDVR 46_ GGEPD 51_ GSARR 56_ PRPPC 61_ AKPHK 66_ EGTGQ 71_ QERES 76_ PRPLQ 81_ LPGAE 86_ GPAIS 91_ DGEEG 96_ GGEPG 101_ AGGGA 106_ AGAAG 111_ AGRRD 116_ FVEAP 121_ PPKVN 126_ PWTKN 131_ ALPPV 136_ LTTVN 141_ GQSPP 146_ EHSAP 151_ AKVVR 156_ AAVPK 161_ QRKGS 166_ KVGDF 171_ GDAIN 176_ WPTPG 181_ EIAHK 186_ SVQPQ 191_ SHKPQ 196_ PTRKL 201_ PPKKD 206_ MKEQE 211_ KGEGS 216_ DSKES 221_ PKTKS 226_ DESGE 231_ EKNGD 236_ EDCQR 241_ GGQKK 246_ KGNKH 251_ KWVPL 256_ QIDMK 261_ PEVPR 266_ EKLAS 271_ RPTRP 276_ PEPRH 281_ IPANR 286_ GEIKG 291_ SESAT 296_ YVPVA 301_ PPTPA 306_ WQPEI 311_ KPEPA 316_ WHDQD 321_ ETSSV 326_ KSDGA 331_ GGARA 336_ SFRGR 341_ GRGRG 346_ RGRGR 351_ GRGGT 356_ RTHFD 361_ YQFGY 366_ RKFDG 371_ VEGPR 376_ TPKYM 381_ NNITY 386_ YFDNV 391_ SSTEL 396_ YSVDQ 401_ ELLKD 406_ YIKRQ 411_ IEYYF 416_ SVDNL 421_ ERDFF 426_ LRRKM 431_ DADGF 436_ LPITL 441_ IASFH 446_ RVQAL 451_ TTDIS 456_ LIFAA 461_ LKDSK 466_ VVEIV 471_ DEKVR 476_ RREEP 481_ EKWPL 486_ PPIVD 491_ YSQTD 496_ FSQLL 501_ NCPEF 506_ VPRQH 511_ YQKET 516_ ESAPG 521_ SPRAV 526_ TPVPT 531_ KTEEV 536_ SNLKT 541_ LPKGL 546_ SASLP 551_ DLDSE 556_ NWIEV 561_ KKRPR 566_ PSPAR 571_ PKKSE 576_ ESRFS 581_ HLTSL 586_ PQQLP 591_ SQQLM 596_ SKDQD 601_ EQEEL 606_ DFLFD 611_ EEMEQ 616_ MDGRK 621_ NTFTA 626_ WSDEE 631_ SDYEI 636_ DDRDV 641_ NKILI 646_ VTQTP 651_ HYMRR 656_ HPGGD 661_ RTGNH 666_ TSRAK 671_ MSAEL 676_ AKVIN 681_ DGLFY 686_ YEQDL 691_ WAEKF 696_ EPEYS 701_ QIKQE 706_ VENFK 711_ KVNMI 716_ SREQF 721_ DTLTP 726_ EPPVD 731_ PNQEV 736_ PPGPP 741_ RFQQV 746_ PTDAL 751_ ANKLF 756_ GAPEP 761_ STIAR 766_ SLPTT 771_ VPESP 776_ NYRNT 781_ RTPRT 786_ PRTPQ 791_ LKDSS 796_ QTSRF 801_ YPVVK 806_ EGRTL 811_ DAKMP 816_ RKRKT 821_ RHSSN 826_ PPLES 831_ HVGWV 836_ MDSRE 841_ HRPRT 846_ ASISS 851_ SPSEG 856_ TPTVG 861_ SYGCT 866_ PQSLP 871_ KFQHP 876_ SHELL 881_ KENGF 886_ TQHVY 891_ HKYRR 896_ RCLNE 901_ RKRLG 906_ IGQSQ 911_ EMNTL 916_ FRFWS 921_ FFLRD 926_ HFNKK 931_ MYEEF 936_ KQLAL 941_ EDAKE 946_ GYRYG 951_ LECLF 956_ RYYSY 961_ GLEKK 966_ FRLDI 971_ FKDFQ 976_ EETVK 981_ DYEAG 986_ QLYGL 991_ EKFWA 996_ FLKYS 1001_ KAKNL 1006_ DIDPK 1011_ LQEYL 1016_ GKFRR 1021_ LEDFR 1026_ VDPPM 1031_ GEEGN 1036_ HKRHS 1041_ VVAGG 1046_ GGGEG 1051_ RKRCP 1056_ SQSSS 1061_ RPAAM 1066_ ISQPP 1071_ TPPTG 1076_ QPVRE 1081_ DAKWT 1086_ SQHSN 1091_TQTLG
1: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543)
2: (Microbial infection) Positively regulates the replication of dengue virus (DENV)