Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein)
1_MDFVA 6_ GAIGG 11_ VCGVA 16_ VGYPL 21_ DTVKV 26_ RIQTE 31_ PKYTG 36_ IWHCV 41_ RDTYH 46_ RERVW 51_ GFYRG 56_ LSLPV 61_ CTVSL 66_ VSSVS 71_ FGTYR 76_ HCLAH 81_ ICRLR 86_ YGNPD 91_ AKPTK 96_ ADITL 101_ SGCAS 106_ GLVRV 111_ FLTSP 116_ TEVAK 121_ VRLQT 126_ QTQAQ 131_ KQQRR 136_ LSASG 141_ PLAVP 146_ PMCPV 151_ PPACP 156_ EPKYR 161_ GPLHC 166_ LATVA 171_ REEGL 176_ CGLYK 181_ GSSAL 186_ VLRDG 191_ HSFAT 196_ YFLSY 201_ AVLCE 206_ WLSPA 211_ GHSRP 216_ DVPGV 221_ LVAGG 226_ CAGVL 231_ AWAVA 236_ TPMDV 241_ IKSRL 246_ QADGQ 251_ GQRRY 256_ RGLLH 261_ CMVTS 266_ VREEG 271_ PRVLF 276_ KGLVL 281_ NCCRA 286_ FPVNM 291_ VVFVA 296_ YEAVL 301_RLARG
1: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated