Aminopeptidase Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2 antigen) (Laeverin)
1_MGPPS 6_ SSGFY 11_ VSRAV 16_ ALLLA 21_ GLVAA 26_ LLLAL 31_ AVLAA 36_ LYGHC 41_ ERVPP 46_ SELPG 51_ LRDLE 56_ AESSP 61_ PLRQK 66_ PTPTP 71_ KPSSA 76_ RELAV 81_ TTTPS 86_ NWRPP 91_ GPWDQ 96_ LRLPP 101_ WLVPL 106_ HYDLE 111_ LWPQL 116_ RPDEL 121_ PAGSL 126_ PFTGR 131_ VNITV 136_ RCTVA 141_ TSRLL 146_ LHSLF 151_ QDCER 156_ AEVRG 161_ PLSPG 166_ TGNAT 171_ VGRVP 176_ VDDVW 181_ FALDT 186_ EYMVL 191_ ELSEP 196_ LKPGS 201_ SYELQ 206_ LSFSG 211_ LVKED 216_ LREGL 221_ FLNVY 226_ TDQGE 231_ RRALL 236_ ASQLE 241_ PTFAR 246_ YVFPC 251_ FDEPA 256_ LKATF 261_ NITMI 266_ HHPSY 271_ VALSN 276_ MPKLG 281_ QSEKE 286_ DVNGS 291_ KWTVT 296_ TFSTT 301_ PHMPT 306_ YLVAF 311_ VICDY 316_ DHVNR 321_ TERGK 326_ EIRIW 331_ ARKDA 336_ IANGS 341_ ADFAL 346_ NITGP 351_ IFSFL 356_ EDLFN 361_ ISYSL 366_ PKTDI 371_ IALPS 376_ FDNHA 381_ MENWG 386_ LMIFD 391_ ESGLL 396_ LEPKD 401_ QLTEK 406_ KTLIS 411_ YVVSH 416_ EIGHQ 421_ WFGNL 426_ VTMNW 431_ WNNIW 436_ LNEGF 441_ ASYFE 446_ FEVIN 451_ YFNPK 456_ LPRNE 461_ IFFSN 466_ ILHNI 471_ LREDH 476_ ALVTR 481_ AVAMK 486_ VENFK 491_ TSEIQ 496_ ELFDI 501_ FTYSK 506_ GASMA 511_ RMLSC 516_ FLNEH 521_ LFVSA 526_ LKSYL 531_ KTFSY 536_ SNAEQ 541_ DDLWR 546_ HFQMA 551_ IDDQS 556_ TVILP 561_ ATIKN 566_ IMDSW 571_ THQSG 576_ FPVIT 581_ LNVST 586_ GVMKQ 591_ EPFYL 596_ ENIKN 601_ RTLLT 606_ SNDTW 611_ IVPIL 616_ WIKNG 621_ TTQPL 626_ VWLDQ 631_ SSKVF 636_ PEMQV 641_ SDSDH 646_ DWVIL 651_ NLNMT 656_ GYYRV 661_ NYDKL 666_ GWKKL 671_ NQQLE 676_ KDPKA 681_ IPVIH 686_ RLQLI 691_ DDAFS 696_ LSKNN 701_ YIEIE 706_ TALEL 711_ TKYLA 716_ EEDEI 721_ IVWHT 726_ VLVNL 731_ VTRDL 736_ VSEVN 741_ IYDIY 746_ SLLKR 751_ YLLKR 756_ LNLIW 761_ NIYST 766_ IIREN 771_ VLALQ 776_ DDYLA 781_ LISLE 786_ KLFVT 791_ ACWLG 796_ LEDCL 801_ QLSKE 806_ LFAKW 811_ VDHPE 816_ NEIPY 821_ PIKDV 826_ VLCYG 831_ IALGS 836_ DKEWD 841_ ILLNT 846_ YTNTT 851_ NKEEK 856_ IQLAY 861_ AMSCS 866_ KDPWI 871_ LNRYM 876_ EYAIS 881_ TSPFT 886_ SNETN 891_ IIEVV 896_ ASSEV 901_ GRYVA 906_ KDFLV 911_ NNWQA 916_ VSKRY 921_ GTQSL 926_ INLIY 931_ TIGRT 936_ VTTDL 941_ QIVEL 946_ QQFFS 951_ NMLEE 956_ HQRIR 961_ VHANL 966_ QTIKN 971_ ENLKN 976_ KKLSA 981_RIAAW
1: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C