Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)
1_MESTG 6_ SVGEA 11_ PGGPR 16_ VLVVG 21_ GGIAG 26_ LGAAQ 31_ RLCGH 36_ SAFPH 41_ LRVLE 46_ ATARA 51_ GGRIR 56_ SERCF 61_ GGVVE 66_ VGAHW 71_ IHGPS 76_ RGNPV 81_ FQLAA 86_ EYGLL 91_ GEKEL 96_ SQENQ 101_ LVETG 106_ GHVGL 111_ PSVSY 116_ ASSGA 121_ SVSLQ 126_ LVAEM 131_ ATLFY 136_ GLIDQ 141_ TREFL 146_ HAAET 151_ PVPSV 156_ GEYLK 161_ KEIGQ 166_ HVAGW 171_ TEDEE 176_ TRKLK 181_ LAVLN 186_ SFFNL 191_ ECCVS 196_ GTHSM 201_ DLVAL 206_ APFGE 211_ YTVLP 216_ GLDCT 221_ FSKGY 226_ QGLTN 231_ CMMAA 236_ LPEDT 241_ VVFEK 246_ PVKTI 251_ HWNGS 256_ FQEAA 261_ FPGET 266_ FPVSV 271_ ECEDG 276_ DRFPA 281_ HHVIV 286_ TVPLG 291_ FLREH 296_ LDTFF 301_ DPPLP 306_ AEKAE 311_ AIRKI 316_ GFGTN 321_ NKIFL 326_ EFEEP 331_ FWEPD 336_ CQLIQ 341_ LVWED 346_ TSPLE 351_ DAAPE 356_ LQDAW 361_ FRKLI 366_ GFVVL 371_ PAFAS 376_ VHVLC 381_ GFIAG 386_ LESEF 391_ METLS 396_ DEEVL 401_ LCLTQ 406_ VLRRV 411_ TGNPR 416_ LPAPK 421_ SVLRS 426_ RWHSA 431_ PYTRG 436_ SYSYV 441_ AVGST 446_ GGDLD 451_ LLAQP 456_ LPADG 461_ AGAQL 466_ QILFA 471_ GEATH 476_ RTFYS 481_ TTHGA 486_ LLSGW 491_ READR 496_ LLSLW 501_ APQVQ 506_QPRPR
1: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380)