Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa)
1_MDPAP 6_ GVLDP 11_ RAAPP 16_ ALLGT 21_ PQAEV 26_ LEDVL 31_ REQFG 36_ PLPQL 41_ AAVCR 46_ LKRLP 51_ SGGYS 56_ STENL 61_ QLVLE 66_ RRRVA 71_ NAKER 76_ ERIKN 81_ LNRGF 86_ ARLKA 91_ LVPFL 96_ PQSRK 101_ PSKVD 106_ ILKGA 111_ TEYIQ 116_ VLSDL 121_ LEGAK 126_ DSKKQ 131_ DPDEQ 136_ SYSNN 141_ SSESH 146_ TSSAR 151_ QLSRN 156_ ITQHI 161_ SCAFG 166_ LKNEE 171_ EGPWA 176_ DGGSG 181_ EPAHA 186_ CRHSV 191_ MSTTE 196_ IISPT 201_ RSLDR 206_ FPEVE 211_LLSHR
1: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters