Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25)
1_MEKLL 6_ RLCCW 11_ YSWLL 16_ LFYYN 21_ FQVRG 26_ VYSRS 31_ QDHPG 36_ FQVLA 41_ SASHY 46_ WPLEN 51_ VDGIH 56_ ELQDT 61_ TGDIV 66_ EGKVN 71_ KGIYL 76_ KEEKG 81_ VTLLY 86_ YGRYN 91_ SSCIS 96_ KPEQC 101_ GPEGV 106_ TFSFF 111_ WKTQG 116_ EQSRP 121_ IPSAY 126_ GGQVI 131_ SNGFK 136_ VCSSG 141_ GRGSV 146_ ELYTR 151_ DNSMT 156_ WEASF 161_ SPPGP 166_ YWTHV 171_ LFTWK 176_ SKEGL 181_ KVYVN 186_ GTLST 191_ SDPSG 196_ KVSRD 201_ YGESN 206_ VNLVI 211_ GSEQD 216_ QAKCY 221_ ENGAF 226_ DEFII 231_ WERAL 236_ TPDEI 241_ AMYFT 246_ AAIGK 251_ HALLS 256_ STLPS 261_ LFMTS 266_ TASPV 271_ MPTDA 276_ YHPII 281_ TNLTE 286_ ERKTF 291_ QSPGV 296_ ILSYL 301_ QNVSL 306_ SLPSK 311_ SLSEQ 316_ TALNL 321_ TKTFL 326_ KAVGE 331_ ILLLP 336_ GWIAL 341_ SEDSA 346_ VVLSL 351_ IDTID 356_ TVMGH 361_ VSSNL 366_ HGSTP 371_ QVTVE 376_ GSSAM 381_ AEFSV 386_ AKILP 391_ KTVNS 396_ SHYRF 401_ PAHGQ 406_ SFIQI 411_ PHEAF 416_ HRHAW 421_ STVVG 426_ LLYHS 431_ MHYYL 436_ NNIWP 441_ AHTKI 446_ AEAMH 451_ HQDCL 456_ LFATS 461_ HLISL 466_ EVSPP 471_ PTLSQ 476_ NLSGS 481_ PLITV 486_ HLKHR 491_ LTRKQ 496_ HSEAT 501_ NSSNR 506_ VFVYC 511_ AFLDF 516_ SSGEG 521_ VWSNH 526_ GCALT 531_ RGNLT 536_ YSVCR 541_ CTHLT 546_ NFAIL 551_ MQVVP 556_ LELAR 561_ GHQVA 566_ LSSIS 571_ YVGCS 576_ LSVLC 581_ LVATL 586_ VTFAV 591_ LSSVS 596_ TIRNQ 601_ RYHIH 606_ ANLSF 611_ AVLVA 616_ QVLLL 621_ ISFRL 626_ EPGTT 631_ PCQVM 636_ AVLLH 641_ YFFLS 646_ AFAWM 651_ LVEGL 656_ HLYSM 661_ VIKVF 666_ GSEDS 671_ KHRYY 676_ YGMGW 681_ GFPLL 686_ ICIIS 691_ LSFAM 696_ DSYGT 701_ SNNCW 706_ LSLAS 711_ GAIWA 716_ FVAPA 721_ LFVIV 726_ VNIGI 731_ LIAVT 736_ RVISQ 741_ ISADN 746_ YKIHG 751_ DPSAF 756_ KLTAK 761_ AVAVL 766_ LPILG 771_ TSWVF 776_ GVLAV 781_ NGCAV 786_ VFQYM 791_ FATLN 796_ SLQGL 801_ FIFLF 806_ HCLLN 811_ SEVRA 816_ AFKHK 821_ TKVWS 826_ LTSSS 831_ ARTSN 836_ AKPFH 841_ SDLMN 846_ GTRPG 851_ MASTK 856_ LSPWD 861_ KSSHS 866_AHRVD
1: Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271)