Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3)
1_MASQG 6_ RRRRP 11_ LRRPE 16_ TVVPG 21_ EATET 26_ DSERS 31_ ASSSE 36_ EEELY 41_ LGPSG 46_ PTRGR 51_ PTGLR 56_ VAGEA 61_ AETDS 66_ EPEPE 71_ PEPTA 76_ APRDL 81_ PPLVV 86_ QRESA 91_ EEAWG 96_ TEEAP 101_ APAPA 106_ RSLLQ 111_ LRLAE 116_ SQARL 121_ DHDVA 126_ AAVSG 131_ VYRRA 136_ GRDVA 141_ ALASR 146_ LAAAQ 151_ AAGLA 156_ AAHSV 161_ RLARG 166_ DLCAL 171_ AERLD 176_ IVAGC 181_ RLLPD 186_ IRGVP 191_ GTEPE 196_KDPGP
1: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking