Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
1_MAAIG 6_ RGRSL 11_ KNLRV 16_ RGRND 21_ SGEEN 26_ VPLDL 31_ TREPS 36_ DNLRE 41_ ILQNV 46_ ARLQG 51_ VSNMR 56_ KLGHL 61_ NNFTK 66_ LLCDI 71_ GHSEE 76_ KLGFH 81_ YEDII 86_ ICLRL 91_ ALLNE 96_ AKEVR 101_ AAGLR 106_ ALRYL 111_ IQDSS 116_ ILQKV 121_ LKLKV 126_ DYLIA 131_ RCIDI 136_ QQSNE 141_ VERTQ 146_ ALRLV 151_ RKMIT 156_ VNASL 161_ FPSSV 166_ TNSLI 171_ AVGND 176_ GLQER 181_ DRMVR 186_ ACIAI 191_ ICELA 196_ LQNPE 201_ VVALR 206_ GGLNT 211_ ILKNV 216_ IDCQL 221_ SRINE 226_ ALITT 231_ ILHLL 236_ NHPKT 241_ RQYVR 246_ ADVEL 251_ ERILA 256_ PYTDF 261_ HYRHS 266_ PDTAE 271_ GQLKE 276_ DREAR 281_ FLASK 286_ MGIIA 291_ TFRSW 296_ AGIIN 301_ LCKPG 306_ NSGIQ 311_ SLIGV 316_ LCIPN 321_ MEIRR 326_ GLLEV 331_ LYDIF 336_ RLPLP 341_ VVTEE 346_ FIEAL 351_ LSVDP 356_ GRFQD 361_ SWRLS 366_ DGFVA 371_ AEAKT 376_ ILPHR 381_ ARSRP 386_ DLMDN 391_ YLALI 396_ LSAFI 401_ RNGLL 406_ EGLVE 411_ VITNS 416_ DDHIS 421_ VRATI 426_ LLGEL 431_ LHMAN 436_ TILPH 441_ SHSHH 446_ LHCLP 451_ TLMNM 456_ AASFD 461_ IPKEK 466_ RLRAS 471_ AALNC 476_ LKRFH 481_ EMKKR 486_ GPKPY 491_ SLHLD 496_ HIIQK 501_ AIATH 506_ QKRDQ 511_ YLRVQ 516_ KDIFI 521_ LKDTE 526_ EALLI 531_ NLRDS 536_ QVLQH 541_ KENLE 546_ WNWNL 551_ IGTIL 556_ KWPNV 561_ NLRNY 566_ KDEQL 571_ HRFVR 576_ RLLYF 581_ YKPSS 586_ KLYAN 591_ LDLDF 596_ AKAKQ 601_ LTVVG 606_ CQFTE 611_ FLLES 616_ EEDGQ 621_ GYLED 626_ LVKDI 631_ VQWLN 636_ ASSGM 641_ KPERS 646_ LQNNG 651_ LLTTL 656_ SQHYF 661_ LFIGT 666_ LSCHP 671_ HGVKM 676_ LEKCS 681_ VFQCL 686_ LNLCS 691_ LKNQD 696_ HLLKL 701_ TVSSL 706_ DYSRD 711_ GLARV 716_ ILSKI 721_ LTAAT 726_ DACRL 731_ YATKH 736_ LRVLL 741_ RANVE 746_ FFNNW 751_ GIELL 756_ VTQLH 761_ DKNKT 766_ ISSEA 771_ LDILD 776_ EACED 781_ KANLH 786_ ALIQM 791_ KPALS 796_ HLGDK 801_ GLLLL 806_ LRFLS 811_ IPKGF 816_ SYLNE 821_ RGYVA 826_ KQLEK 831_ WHREY 836_ NSKYV 841_ DLIEE 846_ QLNEA 851_ LTTYR 856_ KPVDG 861_ DNYVR 866_ RSNQR 871_ LQRPH 876_ VYLPI 881_ HLYGQ 886_ LVHHK 891_ TGCHL 896_ LEVQN 901_ IITEL 906_ CRNVR 911_ TPDLD 916_ KWEEI 921_ KKLKA 926_ SLWAL 931_ GNIGS 936_ SNWGL 941_ NLLQE 946_ ENVIP 951_ DILKL 956_ AKQCE 961_ VLSIR 966_ GTCVY 971_ VLGLI 976_ AKTKQ 981_ GCDIL 986_ KCHNW 991_ DAVRH 996_ SRKHL 1001_ WPVVP 1006_ DDVEQ 1011_ LCNEL 1016_ SSIPS 1021_ TLSLN 1026_ SESTS 1031_ SRHNS 1036_ ESESV 1041_ PSSMF 1046_ ILEDD 1051_ RFGSS 1056_ STSTF 1061_ FLDIN 1066_ EDTEP 1071_ TFYDR 1076_ SGPIK 1081_ DKNSF 1086_ PFFAS 1091_ SKLVK 1096_ NRILN 1101_ SLTLP 1106_ NKKHR 1111_ SSSDP 1116_ KGGKL 1121_ SSESK 1126_ TSNRR 1131_ IRTLT 1136_ EPSVD 1141_ FNHSD 1146_ DFTPI 1151_ STVQK 1156_ TLQLE 1161_ TSFMG 1166_ NKHIE 1171_ DTGST 1176_ PSIGE 1181_ NDLKF 1186_ TKNFG 1191_ TENHR 1196_ ENTSR 1201_ ERLVV 1206_ ESSTS 1211_ SHMKI 1216_ RSQSF 1221_ NTDTT 1226_ TSGIS 1231_ SMSSS 1236_ PSRET 1241_ VGVDA 1246_ TTMDT 1251_ DCGSM 1256_ STVVS 1261_ TKTIK 1266_ TSHYL 1271_ TPQSN 1276_ HLSLS 1281_ KSNSV 1286_ SLVPP 1291_ GSSHT 1296_ LPRRA 1301_ QSLKA 1306_ PSIAT 1311_ IKSLA 1316_ DCNFS 1321_ YTSSR 1326_ DAFGY 1331_ ATLKR 1336_ LQQQR 1341_ MHPSL 1346_ SHSEA 1351_ LASPA 1356_ KDVLF 1361_ TDTIT 1366_ MKANS 1371_ FESRL 1376_ TPSRF 1381_ MKALS 1386_ YASLD 1391_ KEDLL 1396_ SPINQ 1401_ NTLQR 1406_ SSSVR 1411_ SMVSS 1416_ ATYGG 1421_ SDDYI 1426_ GLALP 1431_ VDIND 1436_ IFQVK 1441_ DIPYF 1446_ QTKNI 1451_ PPHDD 1456_ RGARA 1461_ FAHDA 1466_ GGLPS 1471_ GTGGL 1476_ VKNSF 1481_ HLLRQ 1486_ QMSLT 1491_ EIMNS 1496_ IHSDA 1501_ SLFLE 1506_ STEDT 1511_ GLQEH 1516_ TDDNC 1521_ LYCVC 1526_ IEILG 1531_ FQPSN 1536_ QLSAI 1541_ CSHSD 1546_ FQDIP 1551_ YSDWC 1556_ EQTIH 1561_ NPLEV 1566_ VPSKF 1571_ SGISG 1576_ CSDGV 1581_ SQEGS 1586_ ASSTK 1591_ STELL 1596_ LGVKT 1601_ IPDDT 1606_ PMCRI 1611_ LLRKE 1616_ VLRLV 1621_ INLSS 1626_ SVSTK 1631_ CHETG 1636_ LLTIK 1641_ EKYPQ 1646_ TFDDI 1651_ CLYSE 1656_ VSHLL 1661_ SHCTF 1666_ RLPCR 1671_ RFIQE 1676_ LFQDV 1681_ QFLQM 1686_ HEEAE 1691_ AVLAT 1696_ PPKQP 1701_IVDTS
1: Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718)