Ubiquitin carboxyl-terminal hydrolase 17 (USP17) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2)
1_MEDDS 6_ LYLGG 11_ EWQFN 16_ HFSKL 21_ TSSRP 26_ DAAFA 31_ EIQRT 36_ SLPEK 41_ SPLSS 46_ EARVD 51_ LCDDL 56_ APVAR 61_ QLAPR 66_ KKLPL 71_ SSRRP 76_ AAVGA 81_ GLQNM 86_ GNTCY 91_ ENASL 96_ QCLTY 101_ TPPLA 106_ NYMLS 111_ REHSQ 116_ TCQRP 121_ KCCML 126_ CTMQA 131_ HITWA 136_ LHSPG 141_ HVIQP 146_ SQALA 151_ AGFHR 156_ GKQED 161_ AHEFL 166_ MFTVD 171_ AMKKA 176_ CLPGH 181_ KQVDH 186_ HSKDT 191_ TLIHQ 196_ IFGGC 201_ WRSQI 206_ KCLHC 211_ HGISD 216_ TFDPY 221_ LDIAL 226_ DIQAA 231_ QSVKQ 236_ ALEQL 241_ VKPEE 246_ LNGEN 251_ AYHCG 256_ LCLQR 261_ APASK 266_ TLTLH 271_ TSAKV 276_ LILVL 281_ KRFSD 286_ VTGNK 291_ LAKNV 296_ QYPEC 301_ LDMQP 306_ YMSQQ 311_ NTGPL 316_ VYVLY 321_ AVLVH 326_ AGWSC 331_ HDGHY 336_ FSYVK 341_ AQEGQ 346_ WYKMD 351_ DAKVT 356_ ACSIT 361_ SVLSQ 366_ QAYVL 371_ FYIQK 376_ SEWER 381_ HSESV 386_ SRGRE 391_ PRALG 396_ AEDTD 401_ RRATQ 406_ GELKR 411_ DHPCL 416_ QAPEL 421_ DERLV 426_ ERATQ 431_ ESTLD 436_ HWKFP 441_ QEQNK 446_ TKPEF 451_ NVRKV 456_ EGTLP 461_ PNVLV 466_ IHQSK 471_ YKCGM 476_ KNHHP 481_ EQQSS 486_ LLNLS 491_ STTRT 496_ DQESV 501_ NTGTL 506_ ASLQG 511_ RTRRS 516_ KGKNK 521_HSKRA
1: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection