Double homeobox protein 4C (Double homeobox protein 4, centromeric) (DUX4c) (Double homeobox protein 4-like protein 9)
1_MALPT 6_ PSDST 11_ LPAEA 16_ RGRGR 21_ RRRLV 26_ WTPSQ 31_ SEALR 36_ ACFER 41_ NPYPG 46_ IATRE 51_ RLAQA 56_ IGIPE 61_ PRVQI 66_ WFQNE 71_ RSRQL 76_ RQHRR 81_ ESRPW 86_ PGRRG 91_ PPEGR 96_ RKRTA 101_ VTGSQ 106_ TALLL 111_ RAFEK 116_ DRFPG 121_ IAARE 126_ ELARE 131_ TGLPE 136_ SRIQI 141_ WFQNR 146_ RARHP 151_ GQGGR 156_ APAQA 161_ GGLCS 166_ AAPGG 171_ GHPAP 176_ SWVAF 181_ AHTGA 186_ WGTGL 191_ PAPHV 196_ PCAPG 201_ ALPQG 206_ AFVSQ 211_ AARAA 216_ PALQP 221_ SQAAP 226_ AEGIS 231_ QPAPA 236_ RGDFA 241_ YAAPA 246_ PPDGA 251_ LSHPQ 256_ APRWP 261_ PHPGK 266_ SREDR 271_ DPQRD 276_ GLPGP 281_ CAVAQ 286_ PGPAQ 291_ AGPQG 296_ QGVLA 301_ PPTSQ 306_ GSPWW 311_ GWGRG 316_ PQVAG 321_ AAWEP 326_ QAGAA 331_ PPPQP 336_ APPDA 341_ SAAST 346_ DASHP 351_ GASQP 356_ LQEPG 361_ RSSTV 366_TSSLL
1: Down-regulates MYOD1 expression and may up-regulate MYF5 expression (PubMed:19829708). May regulate microRNA (miRNA) transcription, up-regulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206 (PubMed:24145033). Impairs the differentiation of myoblasts and may be involved in muscle regeneration (PubMed:18723017, PubMed:36882853). Reduces DUX4-induced nuclear localization of CTNNB1/beta-catenin and its subsequent activation of target genes (PubMed:36158201)