Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)
1_MAGPP 6_ ALPPP 11_ ETAAA 16_ ATTAA 21_ AASSS 26_ AASPH 31_ YQEWI 36_ LDTID 41_ SLRSR 46_ KARPD 51_ LERIC 56_ RMVRR 61_ RHGPE 66_ PERTR 71_ AELEK 76_ LIQQR 81_ AVLRV 86_ SYKGS 91_ ISYRN 96_ AARVQ 101_ PPRRG 106_ ATPPA 111_ PPRAP 116_ RGAPA 121_ AAAAA 126_ APPPT 131_ PAPPP 136_ PPAPV 141_ AAAAP 146_ ARAPR 151_ AAAAA 156_ ATAPP 161_ SPGPA 166_ QPGPR 171_ AQRAA 176_ PLAAP 181_ PPAPA 186_ APPAV 191_ APPAG 196_ PRRAP 201_ PPAVA 206_ AREPP 211_ LPPPP 216_ QPPAP 221_ PQQQQ 226_ PPPPQ 231_ PQPPP 236_ EGGAV 241_ RAGGA 246_ ARPVS 251_ LREVV 256_ RYLGG 261_ SGGAG 266_ GRLTR 271_ GRVQG 276_ LLEEE 281_ AAARG 286_ RLERT 291_ RLGAL 296_ ALPRG 301_ DRPGR 306_ APPAA 311_ SARPS 316_ RSKRG 321_ GEERV 326_ LEKEE 331_ EEDDD 336_ EDEDE 341_ EDDVS 346_ EGSEV 351_ PESDR 356_ PAGAQ 361_ HHQLN 366_ GERGP 371_ QSAKE 376_ RVKEW 381_ TPCGP 386_ HQGQD 391_ EGRGP 396_ APGSG 401_ TRQVF 406_ SMAAM 411_ NKEGG 416_ TASVA 421_ TGPDS 426_ PSPVP 431_ LPPGK 436_ PALPG 441_ ADGTP 446_ FGCPP 451_ GRKEK 456_ PSDPV 461_ EWTVM 466_ DVVEY 471_ FTEAG 476_ FPEQA 481_ TAFQE 486_ QEIDG 491_ KSLLL 496_ MQRTD 501_ VLTGL 506_ SIRLG 511_ PALKI 516_ YEHHI 521_ KVLQQ 526_ GHFED 531_DDPDG
1: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929)