SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C)
1_MAADE 6_ VAGGA 11_ RKATK 16_ SKLFE 21_ FLVHG 26_ VRPGM 31_ PSGAR 36_ MPHQG 41_ APMGP 46_ PGSPY 51_ MGSPA 56_ VRPGL 61_ APAGM 66_ EPARK 71_ RAAPP 76_ PGQSQ 81_ AQSQG 86_ QPVPT 91_ APARS 96_ RSAKR 101_ RKMAD 106_ KILPQ 111_ RIREL 116_ VPESQ 121_ AYMDL 126_ LAFER 131_ KLDQT 136_ IMRKR 141_ VDIQE 146_ ALKRP 151_ MKQKR 156_ KLRLY 161_ ISNTF 166_ NPAKP 171_ DAEDS 176_ DGSIA 181_ SWELR 186_ VEGKL 191_ LDDPS 196_ KQKRK 201_ FSSFF 206_ KSLVI 211_ ELDKD 216_ LYGPD 221_ NHLVE 226_ WHRTP 231_ TTQET 236_ DGFQV 241_ KRPGD 246_ LSVRC 251_ TLLLM 256_ LDYQP 261_ PQFKL 266_ DPRLA 271_ RLLGL 276_ HTQSR 281_ SAIVQ 286_ ALWQY 291_ VKTNR 296_ LQDSH 301_ DKEYI 306_ NGDKY 311_ FQQIF 316_ DCPRL 321_ KFSEI 326_ PQRLT 331_ ALLLP 336_ PDPIV 341_ INHVI 346_ SVDPS 351_ DQKKT 356_ ACYDI 361_ DVEVE 366_ EPLKG 371_ QMSSF 376_ LLSTA 381_ NQQEI 386_ SALDS 391_ KIHET 396_ IESIN 401_ QLKIQ 406_ RDFML 411_ SFSRD 416_ PKGYV 421_ QDLLR 426_ SQSRD 431_ LKVMT 436_ DVAGN 441_ PEEER 446_ RAEFY 451_ HQPWS 456_ QEAVS 461_ RYFYC 466_ KIQQR 471_ RQELE 476_QSLVV
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)