Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG)
1_MHQKL 6_ LKSAH 11_ YIELG 16_ SYQYW 21_ PVLVP 26_ RGIRL 31_ YTYEQ 36_ IPGSL 41_ KDNPY 46_ ITDGY 51_ RAYLP 56_ SRLCI 61_ KSLFI 66_ LSNET 71_ VNIWS 76_ HLLGF 81_ FLFFT 86_ LGIYD 91_ MTSVL 96_ PSASA 101_ SREDF 106_ VICSI 111_ CLFCF 116_ QVCML 121_ CSVGY 126_ HLFSC 131_ HRSEK 136_ TCRRW 141_ MALDY 146_ AGISI 151_ GILGC 156_ YVSGV 161_ FYAFY 166_ CNNYW 171_ RQVYL 176_ ITVLA 181_ MILAV 186_ FFAQI 191_ HPNYL 196_ TQQWQ 201_ RLRSI 206_ IFCSV 211_ SGYGV 216_ IPTLH 221_ WVWLN 226_ GGIGA 231_ PIVQD 236_ FAPRV 241_ IVMYM 246_ IALLA 251_ FLFYI 256_ SKVPE 261_ RYFPG 266_ QLNYL 271_ GSSHQ 276_ IWHIL 281_ AVVML 286_ YWWHQ 291_ STVYV 296_ MQYRH 301_ SKPCP 306_DYVSH
1: Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus (PubMed:18547165, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:18547165). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (By similarity)