Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)
1_MVLIL 6_ GRRLN 11_ REDLG 16_ VRDSP 21_ ATKRK 26_ VFEMD 31_ PKSLT 36_ GHEFF 41_ DFSSG 46_ SSHAE 51_ NILQI 56_ FNEFR 61_ DSRLF 66_ TDVII 71_ CVEGK 76_ EFPCH 81_ RAVLS 86_ ACSSY 91_ FRAMF 96_ CNDHR 101_ ESREM 106_ LVEIN 111_ GILAE 116_ AMECF 121_ LQYVY 126_ TGKVK 131_ ITTEN 136_ VQYLF 141_ ETSSL 146_ FQISV 151_ LRDAC 156_ AKFLE 161_ EQLDP 166_ CNCLG 171_ IQRFA 176_ DTHSL 181_ KTLFT 186_ KCKNF 191_ ALQTF 196_ EDVSQ 201_ HEEFL 206_ ELDKD 211_ ELIDY 216_ ICSDE 221_ LVIGK 226_ EEMVF 231_ EAVMR 236_ WVYRA 241_ VDLRR 246_ PLLHE 251_ LLTHV 256_ RLPLL 261_ HPNYF 266_ VQTVE 271_ VDQLI 276_ QNSPE 281_ CYQLL 286_ HEARR 291_ YHILG 296_ NEMMS 301_ PRTRP 306_ RRSTG 311_ YSEVI 316_ VVVGG 321_ CERVG 326_ GFNLP 331_ YTECY 336_ DPVTG 341_ EWKSL 346_ AKLPE 351_ FTKSE 356_ YAVCA 361_ LRNDI 366_ LVSGG 371_ RINSR 376_ DVWIY 381_ NSQLN 386_ IWIRV 391_ ASLNK 396_ GRWRH 401_ KMAVL 406_ LGKVY 411_ VVGGY 416_ DGQNR 421_ LSSVE 426_ CYDSF 431_ SNRWT 436_ EVAPL 441_ KEAVS 446_ SPAVT 451_ SCVGK 456_ LFVIG 461_ GGPDD 466_ NTCSD 471_ KVQSY 476_ DPETN 481_ SWLLR 486_ AAIPI 491_ AKRCI 496_ TAVSL 501_ NNLIY 506_ VAGGL 511_ TKAIY 516_ CYDPV 521_ EDYWM 526_ HVQNT 531_ FSRQE 536_ NCGMS 541_ VCNGK 546_ IYILG 551_ GRREN 556_ GEATD 561_ TILCY 566_ DPATS 571_ IITGV 576_ AAMPR 581_ PVSYH 586_ GCVTI 591_HRYNE
1: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372)