Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) (Transmembrane protein 13)
1_MALNH 6_ TALPQ 11_ DERLP 16_ HYLRD 21_ GDPFA 26_ SKLSW 31_ EADLV 36_ AGFYL 41_ TIIGI 46_ LSTFG 51_ NGYVL 56_ YMSSR 61_ RKKKL 66_ RPAEI 71_ MTINL 76_ AVCDL 81_ GISVV 86_ GKPFT 91_ IISCF 96_ CHRWV 101_ FGWIG 106_ CRWYG 111_ WAGFF 116_ FGCGS 121_ LITMT 126_ AVSLD 131_ RYLKI 136_ CYLSY 141_ GVWLK 146_ RKHAY 151_ ICLAA 156_ IWAYA 161_ SFWTT 166_ MPLVG 171_ LGDYV 176_ PEPFG 181_ TSCTL 186_ DWWLA 191_ QASVG 196_ GQVFI 201_ LNILF 206_ FCLLL 211_ PTAVI 216_ VFSYV 221_ KIIAK 226_ VKSSS 231_ KEVAH 236_ FDSRI 241_ HSSHV 246_ LEMKL 251_ TKVAM 256_ LICAG 261_ FLIAW 266_ IPYAV 271_ VSVWS 276_ AFGRP 281_ DSIPI 286_ QLSVV 291_ PTLLA 296_ KSAAM 301_ YNPII 306_ YQVID 311_ YKFAC 316_ CQTGG 321_ LKATK 326_ KKSLE 331_ GFRLH 336_ TVTTV 341_ RKSSA 346_VLEIH
1: G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity)