Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)
1_MEIKD 6_ QGAQM 11_ EPLLP 16_ TRNDE 21_ EAVVD 26_ RGGTR 31_ SILKT 36_ HFEKE 41_ DLEGH 46_ RTLFI 51_ GVHVP 56_ LGGRK 61_ SHRRH 66_ RHRGH 71_ KHRKR 76_ DRERD 81_ SGLED 86_ GRESP 91_ SFDTP 96_ SQRVQ 101_ FILGT 106_ EDDDE 111_ EHIPH 116_ DLFTE 121_ LDEIC 126_ WREGE 131_ DAEWR 136_ ETARW 141_ LKFEE 146_ DVEDG 151_ GERWS 156_ KPYVA 161_ TLSLH 166_ SLFEL 171_ RSCIL 176_ NGTVL 181_ LDMHA 186_ NTLEE 191_ IADMV 196_ LDQQV 201_ SSGQL 206_ NEDVR 211_ HRVHE 216_ ALMKQ 221_ HHHQN 226_ QKKLT 231_ NRIPI 236_ VRSFA 241_ DIGKK 246_ QSEPN 251_ SMDKN 256_ AGQVV 261_ SPQSA 266_ PACVE 271_ NKNDV 276_ SRENS 281_ TVDFS 286_ KGLGG 291_ QQKGH 296_ TSPCG 301_ MKQRH 306_ EKGPP 311_ HQQER 316_ EVDLH 321_ FMKKI 326_ PPGAE 331_ ASNIL 336_ VGELE 341_ FLDRT 346_ VVAFV 351_ RLSPA 356_ VLLQG 361_ LAEVP 366_ IPTRF 371_ LFILL 376_ GPLGK 381_ GQQYH 386_ EIGRS 391_ IATLM 396_ TDEVF 401_ HDVAY 406_ KAKDR 411_ NDLVS 416_ GIDEF 421_ LDQVT 426_ VLPPG 431_ EWDPS 436_ IRIEP 441_ PKNVP 446_ SQEKR 451_ KIPAV 456_ PNGTA 461_ AHGEA 466_ EPHGG 471_ HSGPE 476_ LQRTG 481_ RIFGG 486_ LILDI 491_ KRKAP 496_ YFWSD 501_ FRDAF 506_ SLQCL 511_ ASFLF 516_ LYCAC 521_ MSPVI 526_ TFGGL 531_ LGEAT 536_ EGRIS 541_ AIESL 546_ FGASM 551_ TGIAY 556_ SLFGG 561_ QPLTI 566_ LGSTG 571_ PVLVF 576_ EKILF 581_ KFCKE 586_ YGLSY 591_ LSLRA 596_ SIGLW 601_ TATLC 606_ IILVA 611_ TDASS 616_ LVCYI 621_ TRFTE 626_ EAFAS 631_ LICII 636_ FIYEA 641_ LEKLF 646_ ELSEA 651_ YPINM 656_ HNDLE 661_ LLTQY 666_ SCNCV 671_ EPHNP 676_ SNGTL 681_ KEWRE 686_ SNISA 691_ SDIIW 696_ ENLTV 701_ SECKS 706_ LHGEY 711_ VGRAC 716_ GHDHP 721_ YVPDV 726_ LFWSV 731_ ILFFS 736_ TVTLS 741_ ATLKQ 746_ FKTSR 751_ YFPTK 756_ VRSIV 761_ SDFAV 766_ FLTIL 771_ CMVLI 776_ DYAIG 781_ IPSPK 786_ LQVPS 791_ VFKPT 796_ RDDRG 801_ WFVTP 806_ LGPNP 811_ WWTVI 816_ AAIIP 821_ ALLCT 826_ ILIFM 831_ DQQIT 836_ AVIIN 841_ RKEHK 846_ LKKGC 851_ GYHLD 856_ LLMVA 861_ VMLGV 866_ CSIMG 871_ LPWFV 876_ AATVL 881_ SITHV 886_ NSLKL 891_ ESECS 896_ APGEQ 901_ PKFLG 906_ IREQR 911_ VTGLM 916_ IFILM 921_ GSSVF 926_ MTSIL 931_ KFIPM 936_ PVLYG 941_ VFLYM 946_ GASSL 951_ KGIQF 956_ FDRIK 961_ LFWMP 966_ AKHQP 971_ DFIYL 976_ RHVPL 981_ RKVHL 986_ FTIIQ 991_ MSCLG 996_ LLWII 1001_ KVSRA 1006_ AIVFP 1011_ MMVLA 1016_ LVFVR 1021_ KLMDL 1026_ LFTKR 1031_ ELSWL 1036_ DDLMP 1041_ ESKKK 1046_ KLEDA 1051_ EKEEE 1056_ QSMLA 1061_ MEDEG 1066_ TVQLP 1071_ LEGHY 1076_ RDDPS 1081_ VINIS 1086_ DEMSK 1091_ TALWR 1096_ NLLIT 1101_ ADNSK 1106_ DKESS 1111_FPSKS
1: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)