Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)
1_MAAPS 6_ GVHLL 11_ VRRGS 16_ HRIFS 21_ SPLNH 26_ IYLHK 31_ QSSSQ 36_ QRRNF 41_ FFRRQ 46_ RDISH 51_ SIVLP 56_ AAVSS 61_ AHPVP 66_ KHIKK 71_ PDYVT 76_ TGIVP 81_ DWGDS 86_ IEVKN 91_ EDQIQ 96_ GLHQA 101_ CQLAR 106_ HVLLL 111_ AGKSL 116_ KVDMT 121_ TEEID 126_ ALVHR 131_ EIISH 136_ NAYPS 141_ PLGYG 146_ GFPKS 151_ VCTSV 156_ NNVLC 161_ HGIPD 166_ SRPLQ 171_ DGDII 176_ NIDVT 181_ VYYNG 186_ YHGDT 191_ SETFL 196_ VGNVD 201_ ECGKK 206_ LVEVA 211_ RRCRD 216_ EAIAA 221_ CRAGA 226_ PFSVI 231_ GNTIS 236_ HITHQ 241_ NGFQV 246_ CPHFV 251_ GHGIG 256_ SYFHG 261_ HPEIW 266_ HHAND 271_ SDLPM 276_ EEGMA 281_ FTIEP 286_ IITEG 291_ SPEFK 296_ VLEDA 301_ WTVVS 306_ LDNQR 311_ SAQFE 316_ HTVLI 321_ TSRGA 326_QILTK
1: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis