Spindle assembly abnormal protein 6 homolog (HsSAS-6)
1_MSQVL 6_ FHQLV 11_ PLQVK 16_ CKDCE 21_ ERRVS 26_ IRMSI 31_ ELQSV 36_ SNPVH 41_ RKDLV 46_ IRLTD 51_ DTDPF 56_ FLYNL 61_ VISEE 66_ DFQSL 71_ KFQQG 76_ LLVDF 81_ LAFPQ 86_ KFIDL 91_ LQQCT 96_ QEHAK 101_ EIPRF 106_ LLQLV 111_ SPAAI 116_ LDNSP 121_ AFLNV 126_ VETNP 131_ FKHLT 136_ HLSLK 141_ LLPGN 146_ DVEIK 151_ KFLAG 156_ CLKCS 161_ KEEKL 166_ SLMQS 171_ LDDAT 176_ KQLDF 181_ TRKTL 186_ AEKKQ 191_ ELDKL 196_ RNEWA 201_ SHTAA 206_ LTNKH 211_ SQELT 216_ NEKEK 221_ ALQAQ 226_ VQYQQ 231_ QHEQQ 236_ KKDLE 241_ ILHQQ 246_ NIHQL 251_ QNRLS 256_ ELEAA 261_ NKDLT 266_ ERKYK 271_ GDSTI 276_ RELKA 281_ KLSGV 286_ EEELQ 291_ RTKQE 296_ VLSLR 301_ RENST 306_ LDVEC 311_ HEKEK 316_ HVNQL 321_ QTKVA 326_ VLEQE 331_ IKDKD 336_ QLVLR 341_ TKEAF 346_ DTIQE 351_ QKVVL 356_ EENGE 361_ KNQVQ 366_ LGKLE 371_ ATIKS 376_ LSAEL 381_ LKANE 386_ IIKKL 391_ QGDLK 396_ TLMGK 401_ LKLKN 406_ TVTIQ 411_ QEKLL 416_ AEKEE 421_ KLQKE 426_ QKELQ 431_ DVGQS 436_ LRIKE 441_ QEVCK 446_ LQEQL 451_ EATVK 456_ KLEES 461_ KQLLK 466_ NNEKL 471_ ITWLN 476_ KELNE 481_ NQLVR 486_ KQDVL 491_ GPSTT 496_ PPAHS 501_ SSNTI 506_ RSGIS 511_ PNLNV 516_ VDGRL 521_ TYPTC 526_ GIGYP 531_ VSSAF 536_ AFQNT 541_ FPHSI 546_ SAKNT 551_ SHPGS 556_ GTKVQ 561_ FNLQF 566_ TKPNA 571_ SLGDV 576_ QSGAT 581_ ISMPC 586_ STDKE 591_ NGENV 596_ GLESK 601_ YLKKR 606_ EDSIP 611_ LRGLS 616_ QNLFS 621_ NSDHQ 626_ RDGTL 631_ GALHT 636_ SSKPT 641_ ALPSA 646_ SSAYF 651_PGQLP
1: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853)