C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
1_MINPE 6_ LRDGR 11_ ADGFI 16_ HRIVP 21_ KLIQN 26_ WKIGL 31_ MCFLS 36_ IIITT 41_ VCIIM 46_ IATWS 51_ KHAKP 56_ VACSG 61_ DWLGV 66_ RDKCF 71_ YFSDD 76_ TRNWT 81_ ASKIF 86_ CSLQK 91_ AELAQ 96_ IDTQE 101_ DMEFL 106_ KRYAG 111_ TDMHW 116_ IGLSR 121_ KQGDS 126_ WKWTN 131_ GTTFN 136_ GWFEI 141_ IGNGS 146_ FAFLS 151_ ADGVH 156_ SSRGF 161_ IDIKW 166_ICSKP
1: Membrane-bound protein expressed mainly on keratinocytes which acts as a ligand to stimulate the activating receptor NKp65/KLRF2, expressed on the surface of natural killer (NK) cells (PubMed:25510854). Facilitates thereby dedicated immune recognition of keratinocytes leading to natural killer cell mediated cytotoxicity (PubMed:20194751). Also plays a role in modulating the extent of T-cell expansion (PubMed:18550855)