Regenerating islet-derived protein 3-gamma (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form]
1_MLPPM 6_ ALPSV 11_ SWMLL 16_ SCLIL 21_ LCQVQ 26_ GEETQ 31_ KELPS 36_ PRISC 41_ PKGSK 46_ AYGSP 51_ CYALF 56_ LSPKS 61_ WMDAD 66_ LACQK 71_ RPSGK 76_ LVSVL 81_ SGAEG 86_ SFVSS 91_ LVRSI 96_ SNSYS 101_ YIWIG 106_ LHDPT 111_ QGSEP 116_ DGDGW 121_ EWSST 126_ DVMNY 131_ FAWEK 136_ NPSTI 141_ LNPGH 146_ CGSLS 151_ RSTGF 156_ LKWKD 161_ YNCDA 166_KLPYV
1: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota
2: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia
3: Has bacteriostatic activity
4: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus