All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) (p18)
1_MAPHD 6_ PGSLT 11_ TLVPW 16_ AAALL 21_ LALGV 26_ ERALA 31_ LPEIC 36_ TQCPG 41_ SVQNL 46_ SKVAF 51_ YCKTT 56_ RELML 61_ HARCC 66_ LNQKG 71_ TILGL 76_ DLQNC 81_ SLEDP 86_ GPNFH 91_ QAHTT 96_ VIIDL 101_ QANPL 106_ KGDLA 111_ NTFRG 116_ FTQLQ 121_ TLILP 126_ QHVNC 131_ PGGIN 136_ AWNTI 141_ TSYID 146_ NQICQ 151_ GQKNL 156_ CNNTG 161_ DPEMC 166_ PENGS 171_ CVPDG 176_ PGLLQ 181_ CVCAD 186_ GFHGY 191_ KCMRQ 196_ GSFSL 201_ LMFFG 206_ ILGAT 211_ TLSVS 216_ ILLWA 221_TQRRK
1: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)