Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)
1_MRPAP 6_ IALWL 11_ RLVLA 16_ LALVR 21_ PRAVG 26_ WAPVR 31_ APIYV 36_ SSWAV 41_ QVSQG 46_ NREVE 51_ RLARK 56_ FGFVN 61_ LGPIF 66_ PDGQY 71_ FHLRH 76_ RGVVQ 81_ QSLTP 86_ HWGHR 91_ LHLKK 96_ NPKVQ 101_ WFQQQ 106_ TLQRR 111_ VKRSV 116_ VVPTD 121_ PWFSK 126_ QWYMN 131_ SEAQP 136_ DLSIL 141_ QAWSQ 146_ GLSGQ 151_ GIVVS 156_ VLDDG 161_ IEKDH 166_ PDLWA 171_ NYDPL 176_ ASYDF 181_ NDYDP 186_ DPQPR 191_ YTPSK 196_ ENRHG 201_ TRCAG 206_ EVAAM 211_ ANNGF 216_ CGVGV 221_ AFNAR 226_ IGGVR 231_ MLDGT 236_ ITDVI 241_ EAQSL 246_ SLQPQ 251_ HIHIY 256_ SASWG 261_ PEDDG 266_ RTVDG 271_ PGILT 276_ REAFR 281_ RGVTK 286_ GRGGL 291_ GTLFI 296_ WASGN 301_ GGLHY 306_ DNCNC 311_ DGYTN 316_ SIHTL 321_ SVGST 326_ TQQGR 331_ VPWYS 336_ EACAS 341_ TLTTT 346_ YSSGV 351_ ATDPQ 356_ IVTTD 361_ LHHGC 366_ TDQHT 371_ GTSAS 376_ APLAA 381_ GMIAL 386_ ALEAN 391_ PFLTW 396_ RDMQH 401_ LVVRA 406_ SKPAH 411_ LQAED 416_ WRTNG 421_ VGRQV 426_ SHHYG 431_ YGLLD 436_ AGLLV 441_ DTART 446_ WLPTQ 451_ PQRKC 456_ AVRVQ 461_ SRPTP 466_ ILPLI 471_ YIREN 476_ VSACA 481_ GLHNS 486_ IRSLE 491_ HVQAQ 496_ LTLSY 501_ SRRGD 506_ LEISL 511_ TSPMG 516_ TRSTL 521_ VAIRP 526_ LDVST 531_ EGYNN 536_ WVFMS 541_ THFWD 546_ ENPQG 551_ VWTLG 556_ LENKG 561_ YYFNT 566_ GTLYR 571_ YTLLL 576_ YGTAE 581_ DMTAR 586_ PTGPQ 591_ VTSSA 596_ CVQRD 601_ TEGLC 606_ QACDG 611_ PAYIL 616_ GQLCL 621_ AYCPP 626_ RFFNH 631_ TRLVT 636_ AGPGH 641_ TAAPA 646_ LRVCS 651_ SCHAS 656_ CYTCR 661_ GGSPR 666_ DCTSC 671_ PPSST 676_ LDQQQ 681_ GSCMG 686_ PTTPD 691_ SRPRL 696_ RAAAC 701_ PHHRC 706_ PASAM 711_ VLSLL 716_ AVTLG 721_ GPVLC 726_ GMSMD 731_ LPLYA 736_ WLSRA 741_ RATPT 746_KPQVW
1: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity)