E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)
1_MPLFF 6_ RKRKP 11_ SEEAR 16_ KRLEY 21_ QMCLA 26_ KEAGA 31_ DDILD 36_ ISKCE 41_ LSEIP 46_ FGAFA 51_ TCKVL 56_ QKKVL 61_ IVHTN 66_ HLTSL 71_ LPKSC 76_ SLLSL 81_ ATIKV 86_ LDLHD 91_ NQLTA 96_ LPDDL 101_ GQLTA 106_ LQVLN 111_ VERNQ 116_ LMQLP 121_ RSIGN 126_ LTQLQ 131_ TLNVK 136_ DNKLK 141_ ELPDT 146_ VGELR 151_ SLRTL 156_ NISGN 161_ EIQRL 166_ PQMLA 171_ HVRTL 176_ EMLSL 181_ DASAM 186_ VYPPR 191_ EVCGA 196_ GTAAI 201_ LQFLC 206_ KESGL 211_ EYYPP 216_ SQYLL 221_ PILEQ 226_ DGIEN 231_ SRDSP 236_ DGPTD 241_ RFSRE 246_ ELEWQ 251_ NRFSD 256_ YEKRK 261_ EQKML 266_ EKLEF 271_ ERRLE 276_ LGQRE 281_ HTQLL 286_ QQSSS 291_ QKDEI 296_ LQTVK 301_ EEQSR 306_ LEQGL 311_ SEHQR 316_ HLNAE 321_ RQRLQ 326_ EQLKQ 331_ TEQNI 336_ SSRIQ 341_ KLLQD 346_ NQRQK 351_ KSSEI 356_ LKSLE 361_ NERIR 366_ MEQLM 371_ SITQE 376_ ETESL 381_ RRRDV 386_ ASAMQ 391_ QMLTE 396_ SCKNR 401_ LIQMA 406_ YESQR 411_ QNLVQ 416_ QACSS 421_ MAEMD 426_ ERFQQ 431_ ILSWQ 436_ QMDQN 441_ KAISQ 446_ ILQES 451_ AMQKA 456_ AFEAL 461_ QVKKD 466_ LMHRQ 471_ IRSQI 476_ KLIET 481_ ELLQL 486_ TQLEL 491_ KRKSL 496_ DTESL 501_ QEMIS 506_ EQRWA 511_ LSSLL 516_ QQLLK 521_ EKQQR 526_ EEELR 531_ EILTE 536_ LEAKS 541_ ETRQE 546_ NYWLI 551_ QYQRL 556_ LNQKP 561_ LSLKL 566_ QEEGM 571_ ERQLV 576_ ALLEE 581_ LSAEH 586_ YLPIF 591_ AHHRL 596_ SLDLL 601_ SQMSP 606_ GDLAK 611_ VGVSE 616_ AGLQH 621_ EILRR 626_ VQELL 631_ DAARI 636_ QPELK 641_ PPMGE 646_ VVTPT 651_ APQEP 656_ PESVR 661_ PSAPP 666_ AELEV 671_ QASEC 676_ VVCLE 681_ REAQM 686_ IFLNC 691_ GHVCC 696_ CQQCC 701_ QPLRT 706_ CPLCR 711_ QDIAQ 716_RLRIY
1: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098)