SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein)
1_MDTFT 6_ VQDST 11_ AMSWW 16_ RNNFW 21_ IILAV 26_ AIIVV 31_ SVGLG 36_ LILYC 41_ VCKWQ 46_ LRRGK 51_ KWEIA 56_ KPLKH 61_ KQVDE 66_ EKMYE 71_ NVLNE 76_ SPVQL 81_ PPLPP 86_ RNWPS 91_ LEDSS 96_ PQEAP 101_ SQPPA 106_ TYSLV 111_ NKVKN 116_ KKTVS 121_ IPSYI 126_ EPEDD 131_ YDDVE 136_IPANT
1: Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity)