Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)
1_MARPG 6_ MERWR 11_ DRLAL 16_ VTGAS 21_ GGIGA 26_ AVARA 31_ LVQQG 36_ LKVVG 41_ CARTV 46_ GNIEE 51_ LAAEC 56_ KSAGY 61_ PGTLI 66_ PYRCD 71_ LSNEE 76_ DILSM 81_ FSAIR 86_ SQHSG 91_ VDICI 96_ NNAGL 101_ ARPDT 106_ LLSGS 111_ TSGWK 116_ DMFNV 121_ NVLAL 126_ SICTR 131_ EAYQS 136_ MKERN 141_ VDDGH 146_ IININ 151_ SMSGH 156_ RVLPL 161_ SVTHF 166_ YSATK 171_ YAVTA 176_ LTEGL 181_ RQELR 186_ EAQTH 191_ IRATC 196_ ISPGV 201_ VETQF 206_ AFKLH 211_ DKDPE 216_ KAAAT 221_ YEQMK 226_ CLKPE 231_ DVAEA 236_ VIYVL 241_ STPAH 246_ IQIGD 251_IQMRP
1: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones