Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)
1_MHSRG 6_ REIVV 11_ LLNPW 16_ SINEA 21_ VSSYC 26_ TYFIK 31_ QDSKS 36_ FGIMV 41_ SWKGI 46_ YFILT 51_ LFWGS 56_ FFGSI 61_ FMLSP 66_ FLPLM 71_ FVNPS 76_ WYRWI 81_ NNRLV 86_ ATWLT 91_ LPVAL 96_ LETMF 101_ GVKVI 106_ ITGDA 111_ FVPGE 116_ RSVII 121_ MNHRT 126_ RMDWM 131_ FLWNC 136_ LMRYS 141_ YLRLE 146_ KICLK 151_ ASLKG 156_ VPGFG 161_ WAMQA 166_ AAYIF 171_ IHRKW 176_ KDDKS 181_ HFEDM 186_ IDYFC 191_ DIHEP 196_ LQLLI 201_ FPEGT 206_ DLTEN 211_ SKSRS 216_ NAFAE 221_ KNGLQ 226_ KYEYV 231_ LHPRT 236_ TGFTF 241_ VVDRL 246_ REGKN 251_ LDAVH 256_ DITVA 261_ YPHNI 266_ PQSEK 271_ HLLQG 276_ DFPRE 281_ IHFHV 286_ HRYPI 291_ DTLPT 296_ SKEDL 301_ QLWCH 306_ KRWEE 311_ KEERL 316_ RSFYQ 321_ GEKNF 326_ YFTGQ 331_ SVIPP 336_ CKSEL 341_ RVLVV 346_ KLLSI 351_ LYWTL 356_ FSPAM 361_ CLLIY 366_ LYSLV 371_ KWYFI 376_ ITIVI 381_ FVLQE 386_ RIFGG 391_ LEIIE 396_ LACYR 401_ LLHKQ 406_PHLNS
1: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity)