Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase)
1_MRGPA 6_ VLLTV 11_ ALATL 16_ LAPGA 21_ GAPVQ 26_ SQGSQ 31_ NKLLL 36_ VSFDG 41_ FRWNY 46_ DQDVD 51_ TPNLD 56_ AMARD 61_ GVKAR 66_ YMTPA 71_ FVTMT 76_ SPCHF 81_ TLVTG 86_ KYIEN 91_ HGVVH 96_ NMYYN 101_ TTSKV 106_ KLPYH 111_ ATLGI 116_ QRWWD 121_ NGSVP 126_ IWITA 131_ QRQGL 136_ RAGSF 141_ FYPGG 146_ NVTYQ 151_ GVAVT 156_ RSRKE 161_ GIAHN 166_ YKNET 171_ EWRAN 176_ IDTVM 181_ AWFTE 186_ EDLDL 191_ VTLYF 196_ GEPDS 201_ TGHRY 206_ GPESP 211_ ERREM 216_ VRQVD 221_ RTVGY 226_ LRESI 231_ ARNHL 236_ TDRLN 241_ LIITS 246_ DHGMT 251_ TVDKR 256_ AGDLV 261_ EFHKF 266_ PNFTF 271_ RDIEF 276_ ELLDY 281_ GPNGM 286_ LLPKE 291_ GRLEK 296_ VYDAL 301_ KDAHP 306_ KLHVY 311_ KKEAF 316_ PEAFH 321_ YANNP 326_ RVTPL 331_ LMYSD 336_ LGYVI 341_ HGRIN 346_ VQFNN 351_ GEHGF 356_ DNKDM 361_ DMKTI 366_ FRAVG 371_ PSFRA 376_ GLEVE 381_ PFESV 386_ HVYEL 391_ MCRLL 396_ GIVPE 401_ ANDGH 406_ LATLL 411_ PMLHT 416_ ESALP 421_ PDGRP 426_ TLLPK 431_ GRSAL 436_ PPSSR 441_ PLLVM 446_ GLLGT 451_VILLS
1: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12671034, PubMed:12885774, PubMed:15205117, PubMed:16255717, PubMed:28292932). Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:12885774, PubMed:16255717). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity)