Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)
1_MERAV 6_ RVESG 11_ VLVGV 16_ VCLLL 21_ ACPAT 26_ ATGPE 31_ VAQPE 36_ VDTTL 41_ GRVRG 46_ RQVGV 51_ KGTDR 56_ LVNVF 61_ LGIPF 66_ AQPPL 71_ GPDRF 76_ SAPHP 81_ AQPWE 86_ GVRDA 91_ STAPP 96_ MCLQD 101_ VESMN 106_ SSRFV 111_ LNGKQ 116_ QIFSV 121_ SEDCL 126_ VLNVY 131_ SPAEV 136_ PAGSG 141_ RPVMV 146_ WVHGG 151_ ALITG 156_ AATSY 161_ DGSAL 166_ AAYGD 171_ VVVVT 176_ VQYRL 181_ GVLGF 186_ FSTGD 191_ EHAPG 196_ NQGFL 201_ DVVAA 206_ LRWVQ 211_ ENIAP 216_ FGGDL 221_ NCVTV 226_ FGGSA 231_ GGSII 236_ SGLVL 241_ SPVAA 246_ GLFHR 251_ AITQS 256_ GVITT 261_ PGIID 266_ SHPWP 271_ LAQKI 276_ ANTLA 281_ CSSSS 286_ PAEMV 291_ QCLQQ 296_ KEGEE 301_ LVLSK 306_ KLKNT 311_ IYPLT 316_ VDGTV 321_ FPKSP 326_ KELLK 331_ EKPFH 336_ SVPFL 341_ MGVNN 346_ HEFSW 351_ LIPRG 356_ WGLLD 361_ TMEQM 366_ SREDM 371_ LAIST 376_ PVLTS 381_ LDVPP 386_ EMMPT 391_ VIDEY 396_ LGSNS 401_ DAQAK 406_ CQAFQ 411_ EFMGD 416_ VFINV 421_ PTVSF 426_ SRYLR 431_ DSGSP 436_ VFFYE 441_ FQHRP 446_ SSFAK 451_ IKPAW 456_ VKADH 461_ GAEGA 466_ FVFGG 471_ PFLMD 476_ ESSRL 481_ AFPEA 486_ TEEEK 491_ QLSLT 496_ MMAQW 501_ THFAR 506_ TGDPN 511_ SKALP 516_ PWPQF 521_ NQAEQ 526_ YLEIN 531_ PVPRA 536_ GQKFR 541_ EAWMQ 546_ FWSET 551_ LPSKI 556_ QQWHQ 561_ KQKNR 566_KAQED
1: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics