Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) (Telethon sulfatase)
1_MLLLW 6_ VSVVA 11_ ALALA 16_ VLAPG 21_ AGEQR 26_ RRAAK 31_ APNVV 36_ LVVSD 41_ SFDGR 46_ LTFHP 51_ GSQVV 56_ KLPFI 61_ NFMKT 66_ RGTSF 71_ LNAYT 76_ NSPIC 81_ CPSRA 86_ AMWSG 91_ LFTHL 96_ TESWN 101_ NFKGL 106_ DPNYT 111_ TWMDV 116_ MERHG 121_ YRTQK 126_ FGKLD 131_ YTSGH 136_ HSISN 141_ RVEAW 146_ TRDVA 151_ FLLRQ 156_ EGRPM 161_ VNLIR 166_ NRTKV 171_ RVMER 176_ DWQNT 181_ DKAVN 186_ WLRKE 191_ AINYT 196_ EPFVI 201_ YLGLN 206_ LPHPY 211_ PSPSS 216_ GENFG 221_ SSTFH 226_ TSLYW 231_ LEKVS 236_ HDAIK 241_ IPKWS 246_ PLSEM 251_ HPVDY 256_ YSSYT 261_ KNCTG 266_ RFTKK 271_ EIKNI 276_ RAFYY 281_ AMCAE 286_ TDAML 291_ GEIIL 296_ ALHQL 301_ DLLQK 306_ TIVIY 311_ SSDHG 316_ ELAME 321_ HRQFY 326_ KMSMY 331_ EASAH 336_ VPLLM 341_ MGPGI 346_ KAGLQ 351_ VSNVV 356_ SLVDI 361_ YPTML 366_ DIAGI 371_ PLPQN 376_ LSGYS 381_ LLPLS 386_ SETFK 391_ NEHKV 396_ KNLHP 401_ PWILS 406_ EFHGC 411_ NVNAS 416_ TYMLR 421_ TNHWK 426_ YIAYS 431_ DGASI 436_ LPQLF 441_ DLSSD 446_ PDELT 451_ NVAVK 456_ FPEIT 461_ YSLDQ 466_ KLHSI 471_ INYPK 476_ VSASV 481_ HQYNK 486_ EQFIK 491_ WKQSI 496_ GQNYS 501_ NVIAN 506_ LRWHQ 511_ DWQKE 516_ PRKYE 521_ NAIDQ 526_ WLKTH 531_MNPRA
1: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (PubMed:23986440). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:28055182, PubMed:34916232). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (PubMed:28055182)