BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)
1_MEGES 6_ TSAVL 11_ SGFVL 16_ GALAF 21_ QHLNT 26_ DSDTE 31_ GFLLG 36_ EVKGE 41_ AKNSI 46_ TDSQM 51_ DDVEV 56_ VYTID 61_ IQKYI 66_ PCYQL 71_ FSFYN 76_ SSGEV 81_ NEQAL 86_ KKILS 91_ NVKKN 96_ VVGWY 101_ KFRRH 106_ SDQIM 111_ TFRER 116_ LLHKN 121_ LQEHF 126_ SNQDL 131_ VFLLL 136_ TPSII 141_ TESCS 146_ THRLE 151_ HSLYK 156_ PQKGL 161_ FHRVP 166_ LVVAN 171_ LGMSE 176_ QLGYK 181_ TVSGS 186_ CMSTG 191_ FSRAV 196_ QTHSS 201_ KFFEE 206_ DGSLK 211_ EVHKI 216_ NEMYA 221_ SLQEE 226_ LKSIC 231_ KKVED 236_ SEQAV 241_ DKLVK 246_ DVNRL 251_ KREIE 256_ KRRGA 261_ QIQAA 266_ REKNI 271_ QKDPQ 276_ ENIFL 281_ CQALR 286_ TFFPN 291_ SEFLH 296_ SCVMS 301_ LKNRH 306_ VSKSS 311_ CNYNH 316_ HLDVV 321_ DNLTL 326_ MVEHT 331_ DIPEA 336_ SPAST 341_ PQIIK 346_ HKALD 351_ LDDRW 356_ QFKRS 361_ RLLDT 366_ QDKRS 371_ KADTG 376_ SSNQD 381_ KASKM 386_ SSPET 391_ DEEIE 396_ KMKGF 401_GEYSR
1: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX