Protein LMBR1L (Limb region 1 protein homolog-like) (Lipocalin-1-interacting membrane receptor) (LIMR)
1_MEAPD 6_ YEVLS 11_ VREQL 16_ FHERI 21_ RECII 26_ STLLF 31_ ATLYI 36_ LCHIF 41_ LTRFK 46_ KPAEF 51_ TTVDD 56_ EDATV 61_ NKIAL 66_ ELCTF 71_ TLAIA 76_ LGAVL 81_ LLPFS 86_ IISNE 91_ VLLSL 96_ PRNYY 101_ IQWLN 106_ GSLIH 111_ GLWNL 116_ VFLFS 121_ NLSLI 126_ FLMPF 131_ AYFFT 136_ ESEGF 141_ AGSRK 146_ GVLGR 151_ VYETV 156_ VMLML 161_ LTLLV 166_ LGMVW 171_ VASAI 176_ VDKNK 181_ ANRES 186_ LYDFW 191_ EYYLP 196_ YLYSC 201_ ISFLG 206_ VLLLL 211_ VCTPL 216_ GLARM 221_ FSVTG 226_ KLLVK 231_ PRLLE 236_ DLEEQ 241_ LYCSA 246_ FEEAA 251_ LTRRI 256_ CNPTS 261_ CWLPL 266_ DMELL 271_ HRQVL 276_ ALQTQ 281_ RVLLE 286_ KRRKA 291_ SAWQR 296_ NLGYP 301_ LAMLC 306_ LLVLT 311_ GLSVL 316_ IVAIH 321_ ILELL 326_ IDEAA 331_ MPRGM 336_ QGTSL 341_ GQVSF 346_ SKLGS 351_ FGAVI 356_ QVVLI 361_ FYLMV 366_ SSVVG 371_ FYSSP 376_ LFRSL 381_ RPRWH 386_ DTAMT 391_ QIIGN 396_ CVCLL 401_ VLSSA 406_ LPVFS 411_ RTLGL 416_ TRFDL 421_ LGDFG 426_ RFNWL 431_ GNFYI 436_ VFLYN 441_ AAFAG 446_ LTTLC 451_ LVKTF 456_ TAAVR 461_ AELIR 466_ AFGLD 471_ RLPLP 476_ VSGFP 481_QASRK
1: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685)