V-set and transmembrane domain-containing protein 1 (Signal inhibitory receptor on leukocytes-1) (SIRL-1)
1_MTAEF 6_ LSLLC 11_ LGLCL 16_ GYEDE 21_ KKNEK 26_ PPKPS 31_ LHAWP 36_ SSVVE 41_ AESNV 46_ TLKCQ 51_ AHSQN 56_ VTFVL 61_ RKVND 66_ SGYKQ 71_ EQSSA 76_ ENEAE 81_ FPFTD 86_ LKPKD 91_ AGRYF 96_ CAYKT 101_ TASHE 106_ WSESS 111_ EHLQL 116_ VVTDK 121_ HDELE 126_ APSMK 131_ TDTRT 136_ IFVAI 141_ FSCIS 146_ ILLLF 151_ LSVFI 156_ IYRCS 161_ QHSSS 166_ SEEST 171_ KRTSH 176_ SKLPE 181_ QEAAE 186_ ADLSN 191_ MERVS 196_ LSTAD 201_ PQGVT 206_ YAELS 211_ TSALS 216_ EAASD 221_ TTQEP 226_ PGSHE 231_YAALK
1: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17)
2: Inhibitory immune receptor involved in the regulation of phagocytes