ALK and LTK ligand 2 (Augmentor alpha) (AUG-alpha)
1_MRGPG 6_ HPLLL 11_ GLLLV 16_ LGAAG 21_ RGRGG 26_ AEPRE 31_ PADGQ 36_ ALLRL 41_ VVELV 46_ QELRK 51_ HHSAE 56_ HKGLQ 61_ LLGRD 66_ CALGR 71_ AEAAG 76_ LGPSP 81_ EQRVE 86_ IVPRD 91_ LRMKD 96_ KFLKH 101_ LTGPL 106_ YFSPK 111_ CSKHF 116_ HRLYH 121_ NTRDC 126_ TIPAY 131_ YKRCA 136_ RLLTR 141_ LAVSP 146_VCMED
1: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation (PubMed:26418745, PubMed:26630010, PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). Cytokine-binding is sufficient to activate LTK (PubMed:34646012). In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK (PubMed:34646012). Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure (PubMed:34646012, PubMed:34819673)