Thiol S-methyltransferase METTL7B (Methyltransferase-like protein 7B) (EC 2.1.1.9)
1_MDILV 6_ PLLQL 11_ LVLLL 16_ TLPLH 21_ LMALL 26_ GCWQP 31_ LCKSY 36_ FPYLM 41_ AVLTP 46_ KSNRK 51_ MESKK 56_ RELFS 61_ QIKGL 66_ TGASG 71_ KVALL 76_ ELGCG 81_ TGANF 86_ QFYPP 91_ GCRVT 96_ CLDPN 101_ PHFEK 106_ FLTKS 111_ MAENR 116_ HLQYE 121_ RFVVA 126_ PGEDM 131_ RQLAD 136_ GSMDV 141_ VVCTL 146_ VLCSV 151_ QSPRK 156_ VLQEV 161_ RRVLR 166_ PGGVL 171_ FFWEH 176_ VAEPY 181_ GSWAF 186_ MWQQV 191_ FEPTW 196_ KHIGD 201_ GCCLT 206_ RETWK 211_ DLENA 216_ QFSEI 221_ QMERQ 226_ PPPLK 231_ WLPVG 236_PHIMG
1: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol