Ly6/PLAUR domain-containing protein 8
1_MKGIL 6_ VAGIT 11_ AVLVA 16_ AVESL 21_ SCVQC 26_ NSWEK 31_ SCVNS 36_ IASEC 41_ PSHAN 46_ TSCIS 51_ SSASS 56_ SLETP 61_ VRLYQ 66_ NMFCS 71_ AENCS 76_ EETHI 81_ TAFTV 86_ HVSAE 91_ EHFHF 96_ VSQCC 101_ QGKEC 106_ SNTSD 111_ ALDPP 116_ LKNVS 121_ SNAEC 126_ PACYE 131_ SNGTS 136_ CHGKP 141_ WKCYE 146_ EEQCV 151_ FLVAE 156_ LKNDI 161_ ESKSL 166_ VLKGC 171_ SNVSN 176_ ATCQF 181_ LSGEN 186_ KTLGG 191_ VIFRK 196_ FECAN 201_ VNSLT 206_ PTSAP 211_ TTSHN 216_ VGSKA 221_ SLYLL 226_ ALASL 231_LLRGL
1: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis