C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
1_MKVLI 6_ SSLLL 11_ LLPLM 16_ LMSMV 21_ SSSLN 26_ PGVAR 31_ GHRDR 36_ GQASR 41_ RWLQE 46_ GGQEC 51_ ECKDW 56_ FLRAP 61_ RRKFM 66_ TVSGL 71_ PKKQC 76_ PCDHF 81_ KGNVK 86_ KTRHQ 91_ RHHRK 96_ PNKHS 101_ RACQQ 106_ FLKQC 111_QLRSF
1: Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203)
2: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17