WD repeat-containing protein 82
1_MKLTD 6_ SVLRS 11_ FRVAK 16_ VFREN 21_ SDKIN 26_ CFDFS 31_ PNGET 36_ VISSS 41_ DDDSI 46_ VLYDC 51_ QEGKP 56_ KRTLY 61_ SKKYG 66_ VDLIR 71_ YTHAA 76_ NTVVY 81_ SSNKI 86_ DDTIR 91_ YLSLH 96_ DNKYI 101_ RYFPG 106_ HSKRV 111_ VALSM 116_ SPVDD 121_ TFISG 126_ SLDKT 131_ IRLWD 136_ LRSPN 141_ CQGLM 146_ HLQGK 151_ PVCSF 156_ DPEGL 161_ IFAAG 166_ VNSEM 171_ VKLYD 176_ LRSFD 181_ KGPFA 186_ TFKMQ 191_ YDRTC 196_ EWTGL 201_ KFSND 206_ GKLIL 211_ ISTNG 216_ SFIRL 221_ IDAFK 226_ GVVMH 231_ TFGGY 236_ ANSKA 241_ VTLEA 246_ SFTPD 251_ SQFIM 256_ IGSED 261_ GKIHV 266_ WNGES 271_ GIKVA 276_ VLDGK 281_ HTGPI 286_ TCLQF 291_ NPKFM 296_ TFASA 301_ CSNMA 306_FWLPT
1: Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603240, PubMed:39603239). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452)