Inactive caspase-12 (CASP-12)
1_MADEK 6_ PSNGV 11_ LVHMV 16_ KLLIK 21_ TFLDG 26_ IFDDL 31_ MENNV 36_ LNTDE 41_ IHLIG 46_ KCLKF 51_ VVSNA 56_ ENLVD 61_ DITET 66_ AQIAG 71_ KIFRE 76_ HLWNS 81_ KKQLS 86_ SDISS 91_ DGERE 96_ ANMPG 101_ LNIRN 106_ KEFNY 111_ LHNRN 116_ GSELD 121_ LLGMR 126_ DLLEN 131_ LGYSV 136_ VIKEN 141_ LTAQE 146_ METAL 151_ RQFAA 156_ HPEHQ 161_ SSDST 166_ FLVFM 171_ SHSIL 176_ NGICG 181_ TKHWD 186_ QEPDV 191_ LHDDT 196_ IFEIF 201_ NNRNC 206_ QSLKD 211_ KPKVI 216_ IMQAC 221_ RGNGA 226_ GIVWF 231_ TTDSG 236_ KASAD 241_ THGRL 246_ LQGNI 251_ CNDAV 256_ TKAHV 261_ EKDFI 266_ AFKSS 271_ TPHNV 276_ SWRHE 281_ TNGSV 286_ FISQI 291_ IYYFR 296_ EYSWS 301_ HHLEE 306_ IFQKV 311_ QHSFE 316_ TPNIL 321_ TQLPT 326_ IERLS 331_ MTRYF 336_YLFPG
1: May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable)