Gene name: ALKAL1

Uniprot entry:

Q6UXT8

Protein names:

ALK and LTK ligand 1 (Augmentor beta) (AUG-beta)

Protein sequence:

1_MRPLK 6_ PGAPL 11_ PALFL 16_ LALAL 21_ SPHGA 26_ HGRPR 31_ GRRGA 36_ RVTDK 41_ EPKPL 46_ LFLPA 51_ AGAGR 56_ TPSGS 61_ RSAEI 66_ FPRDS 71_ NLKDK 76_ FIKHF 81_ TGPVT 86_ FSPEC 91_ SKHFH 96_ RLYYN 101_ TRECS 106_ TPAYY 111_ KRCAR 116_ LLTRL 121_AVSPL

Protein annotations

Protein functions:

1: Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673). Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation (PubMed:34646012, PubMed:34819673). In contrast to ALKAL2, does not act as a potent physiological ligand for ALK (PubMed:26418745, PubMed:34646012)