GDNF family receptor alpha-like
1_MIVFI 6_ FLAMG 11_ LSLEN 16_ EYTSQ 21_ TNNCT 26_ YLREQ 31_ CLRDA 36_ NGCKH 41_ AWRVM 46_ EDACN 51_ DSDPG 56_ DPCKM 61_ RNSSY 66_ CNLSI 71_ QYLVE 76_ SNFQF 81_ KECLC 86_ TDDFY 91_ CTVNK 96_ LLGKK 101_ CINKS 106_ DNVKE 111_ DKFKW 116_ NLTTR 121_ SHHGF 126_ KGMWS 131_ CLEVA 136_ EACVG 141_ DVVCN 146_ AQLAS 151_ YLKAC 156_ SANGN 161_ PCDLK 166_ QCQAA 171_ IRFFY 176_ QNIPF 181_ NIAQM 186_ LAFCD 191_ CAQSD 196_ IPCQQ 201_ SKEAL 206_ HSKTC 211_ AVNMV 216_ PPPTC 221_ LSVIR 226_ SCQND 231_ ELCRR 236_ HYRTF 241_ QSKCW 246_ QRVTR 251_ KCHED 256_ ENCIS 261_ TLSKQ 266_ DLTCS 271_ GSDDC 276_ KAAYI 281_ DILGT 286_ VLQVQ 291_ CTCRT 296_ ITQSE 301_ ESLCK 306_ IFQHM 311_ LHRKS 316_ CFNYP 321_ TLSNV 326_ KGMAL 331_ YTRKH 336_ ANKIT 341_ LTGFH 346_ SPFNG 351_ EVIYA 356_ AMCMT 361_ VTCGI 366_ LLLVM 371_ VKLRT 376_ SRISS 381_ KARDP 386_SSIQI
1: Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:32661391). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (PubMed:31535977, PubMed:32661391). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:32661391)